Results 301 to 310 of about 116,954 (354)
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Clinical pancreatic islet transplantation
Nature Reviews Endocrinology, 2016Clinical pancreatic islet transplantation can be considered one of the safest and least invasive transplant procedures. Remarkable progress has occurred in both the technical aspects of islet cell processing and the outcomes of clinical islet transplantation.
A M James, Shapiro +2 more
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La Presse Médicale, 2012
Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Type 1 diabetes (T1D) represents 10 to 15% of all forms of diabetes. Its incidence shows a consistent rise in all countries under survey. Evidence for autoimmunity in human T1D relies on the detection of insulitis, of islet cell antibodies, of activated β-cell-specific T lymphocytes and on the association of T1D with a restricted set of class II major ...
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Pancreatic Islet Cell Transplantation
Surgical Clinics of North America, 1978Experience with islet transplantation in experimental animals is extensive. These investigations are summarized as a background for the description of clinical experience with allotransplantation and autotransplantation of human islets of Langerhans.
D E, Sutherland +2 more
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1999
Publisher Summary Appropriately, research with emphasis on the endocrine pancreas has grown; in fact, a virtual explosion of discoveries, regarding pancreas development, has occurred over the past few years. The goal in this field is to identify the molecular events that govern pancreas functionality and the genetic components that delineate these ...
D E, Bramblett, H P, Huang, M J, Tsai
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Publisher Summary Appropriately, research with emphasis on the endocrine pancreas has grown; in fact, a virtual explosion of discoveries, regarding pancreas development, has occurred over the past few years. The goal in this field is to identify the molecular events that govern pancreas functionality and the genetic components that delineate these ...
D E, Bramblett, H P, Huang, M J, Tsai
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Pancreatic Islet-Cell Toxicity
CRC Critical Reviews in Toxicology, 1975AbstractA review of pancreatic islet-cell toxicity historically starts with a kidney poison. Dunn et al.,1 while investigating the possible role of some uric acid derivatives in kidney damage, administered alloxan to rabbits. The expected kidney damage was observed and unexpectedly the islets of Langerhans were found to have undergone necrosis.
Lawrence J. Fischer +2 more
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Transplantation of Pancreatic Islets
Annual Review of Immunology, 1984The complications in diabetes mellitus develop over many years. They involve the eye, kidney, and cardiovascular system and may lead to blindness, renal failure, and early development of arteriosclerosis. Apparently these compli cations are secondary to the diabetic state and are due to the inability of our present forms of therapy to maintain the ...
P E, Lacy, J M, Davie
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Lactate Production in Pancreatic Islets
Diabetes, 1998Lactate production, glucose utilization, glucose oxidation, and insulin release were studied in islets from rat and ob/ob mice. Lactate was determined with a highly sensitive method, based on esterification, subsequent separation, and quantitation with high-performance liquid chromatography.
J, Tamarit-Rodriguez +4 more
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PANCREATIC ISLET TRANSPLANTATION
Transplantation, 2003Successful pancreatic islet transplantation (PIT) has resulted in several transplant centers wanting to start PIT programs. PIT remains experimental and must be performed safely for its continued use. We describe the radiographic techniques used at our center and their results.Between January 17, 2002, and December 16, 2002, 17 percutaneous ...
John A, Goss +8 more
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Pancreatic and islet transplantation
Current Gastroenterology Reports, 2000Diabetes mellitus is the most devastating chronic disease of all time. This review discusses the current therapies for type 1 diabetes that are predicated on the restoration of insulin secretion by transplantation. Recent developments in vascularized pancreas transplantation have led to a dramatic increase in the number of these procedures performed ...
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Pancreatic islet xenotransplantation
Drug Discovery Today: Disease Models, 2017This review presents an overview on the present status of xenogeneic islet cell transplantation. In four sections we present (1) a short introduction on clinical islet transplantation using islets from deceased humans, ending with the rationale for xenogeneic islet transplantation; (2) porcine islet survival and function in diabetic nonhuman primates; (
Melanie L. Graham, Henk-Jan Schuurman
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