Results 81 to 90 of about 527,417 (294)

Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

Diabetes, 2013
Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor (VEGF)-A is a critical factor in the development of islet vascularization.
Rachel B. Reinert, M. Brissova, Alena Shostak, F. C. Pan, Greg Poffenberger, Qing Cai, G. L. Hundemer, Jeannelle Kantz, Courtney S. Thompson, C. Dai, O. McGuinness, A. Powers   +11 more
semanticscholar   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

BMC Medical Genetics, 2013
BackgroundInsulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats ...
Elin Hall, T. Dayeh, C. Kirkpatrick, C. Wollheim, M. Dekker Nitert, C. Ling   +5 more
semanticscholar   +1 more source

Nutraceutical Evaluation of Biscuits Formulated From Acha, Chia, and Soycake Flours on Glycemic Control, Lipid Profile, and Histopathological Effects in High‐Fat Diet/Streptozotocin‐Induced Type 2 Diabetic Rats

Food Chemistry International, EarlyView.
Acha–chia–soycake biscuits improved glucose tolerance, lipid profile, insulin levels, and pancreatic integrity in HFD–STZ diabetic rats. ACSB1 and ACSB13 outperformed acarbose, showing potent antihyperglycemic, hypolipidemic, and pancreatic‐protective effects.
Oluwafunmilayo Christianah Ogunnowo, Olufunmilayo Sade Omoba, Aderonke Ibidunni Olagunju, Olamide Wilson Fasakin, Idowu Sunday Oyeleye, Olajide Raymond Ojo   +5 more
wiley   +1 more source

Bioprinting of bespoke islet-specific niches to promote maturation of stem cell-derived islets

Nature Communications
Pancreatic islets are densely packed cellular aggregates containing various hormonal cell types essential for blood glucose regulation. Interactions among these cells markedly affect the glucoregulatory functions of islets along with the surrounding ...
Myungji Kim, Seungyeun Cho, Dong Gyu Hwang, In Kyong Shim, Song Cheol Kim, Jiwon Jang, Jinah Jang   +6 more
doaj   +1 more source

High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets

Diabetes, 2013
Circulating fibroblast growth factor 21 (FGF21) levels are elevated in diabetic subjects and correlate directly with abnormal glucose metabolism, while pharmacologically administered FGF21 can ameliorate hyperglycemia.
W. So, Q. Cheng, Lihua Chen, C. Evans-Molina, A. Xu, K. Lam, P. Leung   +6 more
semanticscholar   +1 more source

Effect of medicinal and food homologous plants polysaccharides on animal nutrition and health: A review

Food Biomacromolecules, EarlyView.
Abstract As one of the most important components of foods, animal meat provides a lot of protein, fat, and energy for humans. However, nutrition and health of animals directly affect the healthiness of human, especially antibiotic residues in animals induced by abuse of antibiotics.
Zichao Wang, Yi Zheng, Changxing Liu, Danye Zhu, Yingjie Feng, Hongtao Zhang, Qi Wang, Qinggong Chen, Xueyi Qiao   +8 more
wiley   +1 more source

Unravelling innervation of pancreatic islets

Diabetologia, 2022
R. F. Hampton, M. Jimenez-Gonzalez, S. Stanley   +2 more
semanticscholar   +1 more source

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

EMBO Journal, 2012
In addition to genetic predisposition, environmental and lifestyle factors contribute to the pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for translating environmental exposures into pathological mechanisms.
Michael Volkmar, S. Dedeurwaerder, D. Cunha, M. Ndlovu, Matthieu Defrance, Rachel Deplus, E. Calonne, Ute Volkmar, M. Igoillo-Esteve, Najib Naamane, S. del Guerra, M. Masini, M. Bugliani, P. Marchetti, M. Cnop, D. Eizirik, F. Fuks   +16 more
semanticscholar   +1 more source

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source