Results 231 to 240 of about 880,817 (296)

Identification of pancreatic lipase inhibitors from Eucommia ulmoides tea by affinity-ultrafiltration combined UPLC-Orbitrap MS and in vitro validation.

Food Chemistry, 2023
Pancreatic lipase inhibitors can reduce blood lipids by inactivating the catalytic activity of human pancreatic lipase, a key enzyme involved in triglyceride hydrolysis, which helps control some dyslipidemic diseases. The ability of Eucommia ulmoides tea
Han Huang, Ming Han, Qi Gu, Jian-Dong Wang, Heng Zhao, Bo-wen Zhai, Si-Ming Nie, Zhi-guo Liu, Yu-Jie Fu   +8 more
semanticscholar   +1 more source

Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice.

International Journal of Biological Macromolecules, 2021
Pancreatic lipase (PL) is a key enzyme related to the prevention and treatment of obesity. The aim of the study was to evaluate the inhibitory effects of mulberry leaf polysaccharides (MLP) on PL and possible interaction mechanism, inhibition on lipid ...
Ruilin Li, Zihan Xue, Yanan Jia, Yajie Wang, Shuqin Li, Jing-Na Zhou, Junyu Liu, Min Zhang, Cheng-Wei He, Hai-Xia Chen   +9 more
semanticscholar   +1 more source

Mechanistic insights into the inhibition of pancreatic lipase by apigenin: inhibitory interaction, conformational change and moleculhfcaar docking studies

Journal of Molecular Liquids, 2021
The inhibition of pancreatic lipase by apigenin, a natural dietary flavonoid, was investigated by various spectroscopic techniques and computational simulation.
Sha Li, Xing Hu, Jun-Hui Pan, D. Gong, Guo-Wen Zhang   +4 more
semanticscholar   +1 more source

Proanthocyanidins as the main pancreatic lipase inhibitors in chokeberry fruits.

Food & Function, 2022
Pancreatic lipase inhibitors are recognized as important in strategies for the management of overweight and obesity. The phytocompounds in chokeberry fruit show multidirectional pro-health effects, including anti-obesity activity.
D. Sosnowska, A. Podsędek, A. Kucharska
semanticscholar   +1 more source

Targeting Obesity with plant-derived pancreatic lipase inhibitors: A comprehensive review.

Pharmacological Research, 2020
The prevalence of obesity is alarmingly increasing in the last few decades and leading to many serious public health concerns worldwide. The dysregulated lipid homeostasis due to various genetic, environmental and lifestyle factors is considered one of ...
Logesh Rajan, Dhanabal S. Palaniswamy, S. Mohankumar   +2 more
semanticscholar   +1 more source

Pancreatic Lipase

2015
International ...
Leger, C., Charles, M.
openaire   +3 more sources

Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation.

International Journal of Biological Macromolecules, 2020
This study aimed to reveal the interaction and inhibitory mechanisms of tangeretin (TAN), nobiletin (NBT), and their acidic hydroxylated forms, 5-demethyltangeretin (5-DT) and 5-demethylnobiletin (5-DN) on porcine pancreatic lipase (PPL) using ...
Xin Huang, Jun-Xiang Zhu, Li Wang, Hui-Juan Jing, Chao-Yang Ma, Xing-Ran Kou, Hong-Xin Wang   +6 more
semanticscholar   +1 more source

The 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) lipase assay in cats and dogs is not specific for pancreatic lipase.

Veterinary clinical pathology, 2020
BACKGROUND The measurement of pancreatic lipase is important for the diagnosis of feline and canine pancreatitis. Recent studies have claimed that lipase assays using the 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methylresorufin) ester (DGGR) as a ...
S. Lim, P. Xenoulis, E. Stavroulaki, J. Lidbury, J. Suchodolski, F. Carrière, J. Steiner   +6 more
semanticscholar   +1 more source

Mechanism of pancreatic lipase action. 1. Interfacial activation of pancreatic lipase

Biochemistry, 1976
Hydrolysis of dissolved p-nitrophenyl acetate by pancreatic lipase follows the classical acyl enzyme pathway already proposed for other esterases. Kinetic parameters of the hydrolysis have been determined. The turnover rate of the reaction is many orders of magnitude slower than that for the natural emulsified substrates.
C, Chapus, M, Sémériva, C, Bovier-Lapierre, P, Desnuelle   +3 more
openaire   +2 more sources

Pancreatic Extract Lipase Activity

JAMA: The Journal of the American Medical Association, 1993
To the Editor. —The use of pancreatic enzyme extracts has decreased maldigestion of fat, as well as macronutrients and micronutrients due to pancreatic insufficiency and alleviated various abdominal symptoms, including steatorrhea, pain associated with alcohol-induced chronic pancreatitis, and distal intestinal obstruction.
E, Lebenthal, R B, Lu, B Y, Zheng, , Khin-Maung-U, A, Madrazo-de la Garza, A, Lerner   +5 more
openaire   +2 more sources