Results 241 to 250 of about 880,817 (296)

Pancreatic lipase-inhibiting protein hydrolysate and peptides from seabuckthorn seed meal: Preparation optimization and inhibitory mechanism

, 2020
Cost-effective natural lipase inhibitors as anti-obesity agents are highly demanded nowadays. This study demonstrated for the first time to produce porcine pancreatic lipase (PPL) inhibitory peptides from low-cost seabuckthorn seed meal by using response
H. Xiang, Dongxiao-Sun Waterhouse, Peng-Zhan Liu, Geoffrey I N Waterhouse, Jiawei Li, Chun Cui   +5 more
semanticscholar   +1 more source

Minireview on pancreatic lipase and colipase

Biochimie, 1988
By hydrolyzing the dietary triacylglycerols, pancreatic lipase causes catalysis in heterogeneous medium. In vivo, lipase action cannot take place without colipase due to the presence of bile salts. The cofactor enables lipase anchoring to the water-lipid interface.
C, Chapus, M, Rovery, L, Sarda, R, Verger   +3 more
openaire   +2 more sources

On The Specificity of Pancreatic Lipase.

Acta Physiologica Scandinavica, 1957
Summary.The substrate specificity of pancreatic lipase has been studied with a series of labelled methyl‐branched fatty acids. The incorporation of a fatty acid into glyceride ester bonds by pancreatic lipase is hindered by a methyl group in the α‐ or β position of the acid.
openaire   +2 more sources

Congenital pancreatic lipase deficiency

The Journal of Pediatrics, 1980
A 5 1/2-year-old boy is reported with congenital lipase deficiency and the presence of colipase. He presented with greasy-oily stools since infancy, but growth and development have been normal. No other cause for exocrine pancreatic insufficiency could be found.
C, Figarella, A, De Caro, D, Leupold, J R, Poley   +3 more
openaire   +2 more sources

Inhibitory effect of quinoa and fenugreek extracts on pancreatic lipase and α-amylase under in vitro traditional conditions or intestinal simulated conditions.

Food Chemistry, 2019
Ethanol extracts (EE) from fenugreek and quinoa seeds with different total content of inhibitory compounds (TIC, total saponin plus phenolic) were prepared with and without concentration of TIC (CEE -concentrated EE-, and EE, respectively).
T. Herrera, Joaquín Navarro del Hierro, T. Fornari, G. Reglero, D. Martín   +4 more
semanticscholar   +1 more source

Structure of human pancreatic lipase

Nature, 1990
Pancreatic lipase (triacylglycerol acyl hydrolase) fulfills a key function in dietary fat absorption by hydrolysing triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids. We have determined the three-dimensional structure of the human enzyme, a single-chain glycoprotein of 449 amino acids, by X-ray crystallography ...
F K, Winkler, A, D'Arcy, W, Hunziker
openaire   +2 more sources

Human pancreatic lipase: A glycoprotein

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1977
Human lipase has been purified from pancreatic juice. The protein has a molecular weight of 48 000 and an N-terminal residue of lysine. It has been characterized as a glycoprotein containing 4.7 mol of glucosamine, 2.8 mol of mannose, 2.9 mol of fucose, 3.0 mol. of galactose and 1.1 mol of glucose per mol of protein.
A, De Caro, C, Figarella, J, Amic, R, Michel, O, Guy   +4 more
openaire   +2 more sources

Studies on human pancreatic lipase

Clinica Chimica Acta, 1966
Abstract Samples of pancreatic juice derived from drainage fluid of patients undergoing pancreatic surgery have been fractionated by gel filtration yielding up to three components showing lipolytic activity against emulsified triglyceride. The “fast” (high molecular weight) lipase fraction has been further studied and has been found to be stable for ...
G P, Fraser, A D, Nicol
openaire   +2 more sources

Discovery of novel amide tripeptides as pancreatic lipase inhibitors by virtual screening

New Journal of Chemistry, 2019
A virtual screening workflow for the discovery of pancreatic lipase inhibitors.
A. Stefanucci, M. P. Dimmito, G. Zengin, G. Luisi, Sako Mirzaie, E. Novellino, A. Mollica   +6 more
semanticscholar   +1 more source

Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors.

Bioorganic chemistry (Print), 2019
A series of eighteen indole glyoxylamide analogues were synthesized, characterized and evaluated for their pancreatic lipase inhibitory activity. Porcine pancreatic lipase (Type II) was used with 4-nitrophenyl butyrate (as substrate) for the in vitro ...
S. Sridhar, Saksham Palawat, A. Paul
semanticscholar   +1 more source