Results 61 to 70 of about 73,057 (319)

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Hybridization of Homogeneous and Heterogeneous Catalysis to Develop a Novel Biocatalyst via Immobilization of Lipase on Surface Modified Mesoporous Silica Towards Biodiesel Synthesis Application

Advanced Energy and Sustainability Research, EarlyView.
The 3‐(methacryloyloxy)propyltrimethoxysilane surface functionalized SBA‐15 (MP‐SBA‐15) is used for the first time as a lipase carrier. The immobilized CAL‐B exhibits high thermal stability and superior catalytic activity. CAL‐B/SBA‐15 suggests that optimum hydrophobicity gives better catalytic activity.
Murugappan N., Ayumi Sato, Jiachen Ge, Arisa Yamada, Makoto Onaka, Yuki Nakamura, Masaru Ogura   +6 more
wiley   +1 more source

Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

Zanco Journal of Medical Sciences, 2020
Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas.
Ahmed Abdulkadir Baban
doaj   +1 more source

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]

, 2012
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C, Dawson, David, Dry, Sarah M, Gier, Belinda, Kirakossian, David, Matveyenko, Aleksey V   +5 more
core   +1 more source

Radium Speciation in Simulated Digestive Biofluids: Insights from Electrospray Ionization Mass Spectrometry and Thermodynamic Modeling

Analysis &Sensing, EarlyView.
Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann, Tim Schmalz, Tobias Weissenborn, Felix Stäger, Beate Riebe, Clemens Walther   +5 more
wiley   +1 more source

Pancreas Cancer-Associated Weight Loss. [PDF]

, 2019
Unintentional weight loss in patients with pancreatic cancer is highly prevalent and contributes to low therapeutic tolerance, reduced quality of life, and overall mortality.
Denlinger, Crystal S, Hendifar, Andrew E, Matrisian, Lynn M, Petzel, Maria QB, Picozzi, Vincent J, Precision Promise Consortium, Rahib, Lola, Zimmers, Teresa A   +7 more
core  

From Lipase Elevation to Diabetes – Pancreatic Involvement during Immune Checkpoint Inhibition [PDF]

, 2023
Sonja Simon, Jochen Utikal
openalex   +1 more source

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

Kinetic Behaviour of Pancreatic Lipase Inhibition by Ultrasonicated A. malaccensis and A. subintegra Leaves of Different Particle Sizes

Bulletin of Chemical Reaction Engineering & Catalysis, 2020
Gallic acid and quercetin equivalent were determined in the crude extract of matured leaves Aquilaria malaccensis and Aquilaria subintegra. The leaves of both Aquilaria species were dried at 60 °C for 24 hours, ground and sieved into particle size of 250,
Miradatul Najwa Muhd Rodhi, Fazlena Hamzah, Ku Halim Ku Hamid   +2 more
doaj   +1 more source

Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study

Annals of Surgery Open
Objective:. To evaluate the diagnostic accuracy of drain fluid lipase as an early predictor of postoperative pancreatic fistula and establish the most appropriate day for their measure. Background:.
Béranger Doussot, MD, Alexandre Doussot, MD, PhD, Ahmet Ayav, MD, PhD, Nicolas Santucci, MD, Sophie Deguelte, MD, Amadou Khalilou Sow, MD, Mehdi El Amrani, MD, PhD, Laurence Duvillard, MD, PhD, Guillaume Piessen, MD, PhD, Edouard Girard, MD, PhD, Jean-Yves Mabrut, MD, PhD, Jonathan Garnier, MD, PhD, Pablo Ortega-Deballon, MD, PhD, Isabelle Fournel, MD, PhD, Olivier Facy, MD, PhD   +14 more
doaj   +1 more source