Results 81 to 90 of about 70,654 (358)

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors. [PDF]

, 2020
PurposeImmune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results of the (nonpancreatic) neuroendocrine neoplasm cohort of SWOG S1609 dual anti-CTLA-4 and ...
Baghdadi, Tareq Al, Blanke, Charles D, Chae, Young Kwang, Chen, Helen X, Fontaine, Annette, Gatalica, Zoran, Giles, Francis J, Hansel, Donna E, Hayward, Jourdain, Kasi, Anup, Korn, W Michael, Kurzrock, Razelle, Matrana, Marc, Mayerson, Edward, McLeod, Christine, Othus, Megan, Patel, Sandip P, Plets, Melissa, Ryan, Christopher W, Shah, Manisha H, Sharon, Elad, Singh, Preet Paul   +21 more
core  

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis

Animal Models and Experimental Medicine, EarlyView.
Tirzepatide: A peptide‐based GLP‐1/GIP receptor agonist, tested on L‐Arginine‐induced pancreatitis. Lipase/Amylase Levels: Initially elevated due to inflammation but normalized with Tirzepatide. Inflammatory Response: Reduction in pro‐inflammatory cytokines (IL‐6) and enhancement of anti‐inflammatory cytokines (IL‐4, IL‐10).
Razan Alawaji, Mohamed S. Abdel‐Bakky, Hussein M. Ali, Miad A. Aljuhani, Abdulaziz Arif A. Alshammari, Hashim K. Kamal, Maamoun M. K. Khoja, Kholoud Alsehemi, Mennatallah A. Korani, Eman S. Said   +9 more
wiley   +1 more source

Kinetic Behaviour of Pancreatic Lipase Inhibition by Ultrasonicated A. malaccensis and A. subintegra Leaves of Different Particle Sizes

Bulletin of Chemical Reaction Engineering & Catalysis, 2020
Gallic acid and quercetin equivalent were determined in the crude extract of matured leaves Aquilaria malaccensis and Aquilaria subintegra. The leaves of both Aquilaria species were dried at 60 °C for 24 hours, ground and sieved into particle size of 250,
Miradatul Najwa Muhd Rodhi, Fazlena Hamzah, Ku Halim Ku Hamid   +2 more
doaj   +1 more source

Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]

, 2014
BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B, Holder, A L, Kennedy, L J, Massey, J, Ollier, W E R, Rothwell, S, Scholey, R, Short, A D   +7 more
core   +2 more sources

Stability and Release Characteristics of Core‐Shell Beads with Emulsion Core Under Gastrointestinal Conditions

Advanced NanoBiomed Research, EarlyView.
A combined emulsion–core‐shell structure system is developed for targeted delivery of lipophilic compounds to the proximal intestine. Using vitamin D3‐loaded sunflower oil emulsions, the core‐shell structure enhances droplet stability, encapsulation efficiency, and gastric protection.
Fariba Malekpour Galogahi, Haotian Cha, Lingxi Ouyang, Nam‐Trung Nguyen   +3 more
wiley   +1 more source

Biochemical properties of pancreatic colipase from the common stingray Dasyatis pastinaca

Lipids in Health and Disease, 2011
Background Pancreatic colipase is a required co-factor for pancreatic lipase, being necessary for its activity during hydrolysis of dietary triglycerides in the presence of bile salts.
Gargouri Youssef, Bou Ali Madiha, Bouchaala Emna, Daoud Lobna, Karray Aida, Ben Bacha Abir, Ben Ali Yassine   +6 more
doaj   +1 more source

Alemtuzumab induction and tacrolimus monotherapy in pancreas transplantation: One- and two-year outcomes [PDF]

, 2006
BACKGROUND. Alemtuzumab (Campath-1H) induction with tacrolimus monotherapy has been shown to provide effective immunosuppression for kidney, liver, lung, and small bowel transplantation.
Abu-Elmagd, Akhtar Khan, Amadeo Marcos, Amit Basu, Calne, Ciano, Deanna Blisard, Flechner, Gruessner, Hale, Henkie P. Tan, John J. Fung, Kaufmann, Kirk, Knechtle, Knechtle, Kusum Tom, Marcos, Marcos, McCurry, Ngoc L. Thai, Ron Shapiro, Shapiro, Shapiro, Starzl, Starzl, Starzl, Starzl, Stuart, Thai, Thomas E. Starzl, Tryphonopoulos, Tzakis, Watson   +33 more
core   +1 more source

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study

Annals of Surgery Open
Objective:. To evaluate the diagnostic accuracy of drain fluid lipase as an early predictor of postoperative pancreatic fistula and establish the most appropriate day for their measure. Background:.
Béranger Doussot, MD, Alexandre Doussot, MD, PhD, Ahmet Ayav, MD, PhD, Nicolas Santucci, MD, Sophie Deguelte, MD, Amadou Khalilou Sow, MD, Mehdi El Amrani, MD, PhD, Laurence Duvillard, MD, PhD, Guillaume Piessen, MD, PhD, Edouard Girard, MD, PhD, Jean-Yves Mabrut, MD, PhD, Jonathan Garnier, MD, PhD, Pablo Ortega-Deballon, MD, PhD, Isabelle Fournel, MD, PhD, Olivier Facy, MD, PhD   +14 more
doaj   +1 more source