Results 91 to 100 of about 861,721 (390)

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Solid Pseudopapillary Tumor of Pancreas in a 14-year-old Adolescent Presenting With Melena: A Case Report [PDF]

Journal of Pediatrics Review, 2023
Background: The incidence of pancreatic neoplasms in infants and children is 1.8 cases per 1000000. Three of children’s most common primary pancreatic neoplasms are pancreatoblastoma, solid pseudopapillary neoplasm of the pancreas, and pancreatic ...
Fateme Fazeli, Emad Asgari Jafarabadi, Amir Hossein Zardast, Marjan Joodi, Ghodsiyeh Azarkar   +4 more
doaj  

Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]

, 2016
Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca, Lanza, Rosina, Lunardi, Gianluigi, Menghi, Antonello, Pecorella, Irene, Rossi, Lorena, Scarpa, Susanna, Sini, Valentina   +7 more
core  

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors

Journal of Pancreatology
The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentiated ...
Jie Chen, Wenming Wu, Chunmei Bai, Yihebali Chi, Li Huo, Liming Jiang, Yuan Ji, Jie Luo, Jie Li, Jingnan Li, Wenhui Lou, Chenghao Shao, Lin Shen, Feng Wang, Yu Wang, Ling Xue, Jin Xu, Chunhui Yuan, Xianjun Yu, Xiaoyu Yin, Hong Zhao, Xiongzeng Zhu, Yupei Zhao   +22 more
doaj   +1 more source

Pancreatic cancer in patient with groove pancreatitis: Potential pitfalls in diagnosis

Radiology Case Reports, 2022
Pancreatic cancer is among the leading causes of cancer death in the United States of America. Early detection and intervention are critical as a large majority of patients have either local or distant metastatic disease at the time of diagnosis. However,
Elias Lugo-Fagundo, BS, Edmund M. Weisberg, MS, MBE, Elliot K. Fishman, MD   +2 more
doaj  

Gastric Outlet Obstruction as the Initial Presentation of Upper Tract Urothelial Carcinoma

Case Reports in Gastrointestinal Medicine, 2020
GOO is often the first sign of advanced upper gastrointestinal neoplasms. The most common neoplasms associated with GOO include gastric, pancreatic, and biliary tract cancers. Urinary tract urothelial carcinoma has been a rarely documented cause of GOO.
Karl Andersen, Sarah Burroughs, Assad Munis, Ryan T. Hoff, Alan Shapiro   +4 more
doaj   +1 more source

Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas) [PDF]

, 2015
OBJECTIVES: Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality.
Aguero Garcete, G., Angiolini, M. R., Araujo Acuna, I., Arcidiacono, P. G., Balzano, G., Bassi, C., Bernier, B., Bissolati, M., Bolado, F., Brugge, W., Campos, V., Casadei, R., Choi, H. J., Concepcion Martin, M., Conwell, D., Crippa, S., De Angelis, C. G., Del Chiaro, M., Delhaye, M., Faccinetto, A., Falconi, M., Fern\ue1ndez Del Castillo, C., Fontana, M., Frigerio, I., Frulloni, L., Gill, R. S., Girelli, R., Gomatos, I., Ha, Y., Hirai, I., Hruban, R., Huggett, M. T., Ikeura, T., Jais, B., Jang, J. Y., Jang, K. T., Jung, W., Kang, C. M., Kang, H., Keane, M. G., Kim, M. H., Kim, S. W., Kimura, W., Kopchak, K. V., L\ue9vy, P., Lee, L. S., Lee, W. J., Lennon, A. M., Leong, R. W., Maggino, L., Malleo, G., Manfredi, R., Marchegiani, G., Matsumoto, I., Messina, O., Milanetto, Anna Caterina, Moon, J. H., Moran, R., Morana, G., Napoleon, B., Neoptolemos, J., Oh, D., Okazaki, K., Oppong, K. W., Osvaldt, A., Oua\uefssi, M., Pavey, D., Pereira, S. P., Pererva, L., Petrone, M. C., Rebours, V., Ricci, C., Rios Vives, M. A., Salvia, R., Sastre, B., Segersvard, R., Shinzeki, M., Song, D. H., Song, S. Y., Spandre, M., Sperti, Cosimo, Tang, J., Urman Fernandez, J. M., Vaquero, E. C., Wang, H., Wolfgang, C., Zaheer, A., Zerbi, A.   +87 more
core   +2 more sources

Metallothionein in Pancreatic Endocrine Neoplasms [PDF]

Modern Pathology, 2000
Metallothioneins (MTs) are intracellular proteins that bind to metal ions and are involved in heavy metal homeostasis and detoxification. Pancreatic islets were shown to be positive for zinc-containing matrix metalloproteinase-2 and -9 by immunocytochemical staining.
openaire   +3 more sources