Results 151 to 160 of about 1,842,584 (317)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Feasibility of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a retrospective cohort study

World Journal of Surgical Oncology
Background There is no evidence supporting the feasibility of laparoscopic pancreaticoduodenectomy (LPD) compared to open pancreatoduodenectomy (OPD) following neoadjuvant chemotherapy (NACT) for pancreatic ductal adenocarcinoma (PDAC).
Zheng Li, Qifeng Zhuo, Borui Li, Mengqi Liu, Chen Chen, Yihua Shi, Wenyan Xu, Wensheng Liu, Shunrong Ji, Xianjun Yu, Xiaowu Xu   +10 more
doaj   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Mitochondrial DNA mutations and intercellular mitochondrial transfer in cancer: mechanisms, biological effects, and clinical potential

Biomarker Research
Mitochondrial DNA (mtDNA) mutations are frequently detected in tumor cells and represent a distinctive aspect of cancer genomics. Common types of mtDNA alterations include single nucleotide variants, insertions and deletions, and copy number changes ...
Yijia Chen, Hanzhe Shi, Mingming Xiao, Haoqi Pan, Xiaoning Yu, Yicheng Zhu, Jing Yang, Wei Wang, Jin Xu, Xianjun Yu, Si Shi   +10 more
doaj   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Pancreatic cancer surgery

BMC Surgery, 2023
Di Martino, Marcello, El Boghdady, Michael   +1 more
openaire   +4 more sources

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study

: Background: Left-sided pancreatic cancer is associated with worse overall survival (OS) compared with right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with resectable pancreatic cancer (RPC ...
Sparrelid, E., Gonz\ue1lez-Ab\uf3s, C., Daams, F., Rodriguez Franco, S., Ricci, C., Suto, H., Tanaka, K., Zerbi, A., Wilmink, J.W., Takishita, C., Wijma, A.G., Takeyama, Y., Bozkurt, E., Cho, Y., Gr\ufctzmann, R., Sutcliffe, R., Kito Fusai, G., Pay\ue1-Llorente, C., Inoue, Y., Hirano, S., Urdzik, J., Kirkov, L., Goodsell, K.E., Sumiyoshi, T., Gramellini, M., van Ramshorst, T.M.E., Halimi, A., Steyerberg, E., Casadei, R., Alberici, L., Wolfgang, C.L., Banerjee, A., H\ufcttner, F.J., Giani, A., Giannone, F., Sartoris, R., Hayashi, M., Rangelova, E., Stommel, M.W.J., Patel, B.Y., Okano, K., Kamei, K., Busch, O.R., Matsumoto, I., Ghorbani, P., Coratti, A., Stoop, T.F., Mora-Oliver, I., de Martino, J., Okada, K., Ramaekers, M., Festen, S., de Franco, L., Hashimoto, D., Fabre, J.M., Davide, J., Frigerio, I., Koh, Y.X., Jang, J.Y., Mizuma, M., Boggi, U., Maglione, M., Sahakyan, M.A., Butturini, G., Takami, H., Miyashita, M., Padbury, R., Tingstedt, B., Mata, R., Ejaz, A., Holka, P.S., Labori, K.J., Verkolf, E., Douchi, D., Souche, F.R., Messersmith, W., Mieog, J.S.D., Takahashi, R., Rojas, A., Chen, J., van Eijck, C.H.J., Amaral, M.J., Jamieson, N.B., Ausania, F., Hartman, Vera, Warren, E., Reames, B.N., Thoma, E., Su\ue1rez-Mu\uf1oz, M.\uc1., Schulick, R.D., de Meijer, V.E., Sergeant, G., van Bodegraven, E.A., Del Pozo, C.D., Kazemier, G., Maithel, S.K., Giardino, A., Kleive, D., Ramera, M., Karsten, T.M., Silva, D.S., Javed, A.A., Kwon, W., Imamura, M., Jain, A., Ome, Y., de Ponthaud, C., Nielsen, K., Franklin, O., Pessaux, P., Hughes, D.L., Burdio, F., Socratous, A., Zhang, C., Bilge, O., Pando, E., D'Hondt, M., Brunner, M., Belyaev, O., Ferrari, G., Thiels, C.A., Motoi, F., Unno, M., Goh, B.K.P., Medin, C., S\ue1nchez-Vel\ue1zquez, P., Abu Hilal, M., Zironda, A., Codjia, T., Sauvanet, A., Honda, G., Nappo, G., Besselink, M.G., Flanking, D., Schwabl, C., Petrikowski, M., van Laarhoven, S., Yamaki, S., Roeyen, Geert, Kilburn, D., Webber, L., Hogg, M.E., Kozono, S., Cab\ufas, S.S., Uemura, K., Edil, B.H., Satoi, S., Sugawara, T., Karteszi, H., Chai, S.M., Luyer, M.D., Kawamoto, Y., Del Chiaro, M., van Dam, M.A., Arshad, A., Bj\uf6rnsson, B., M\ue5nsson, C., Patel, R.B., Serrablo, A., Soonawalla, Z., Kauffman, E.F., Truty, M.J., Ali, M., Moltzer, E., Nagakawa, Y., Sham, J.G., Saliba, G., Bartholom\ue4, W., Janot, M., Murakami, T., Nakamura, T., Gaujoux, S., Oba, A., Berrevoet, F.   +173 more
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