Results 101 to 110 of about 62,032 (298)

Role of contrast-enhanced ultrasound (CEUS) in paediatric practice: an EFSUMB position statement [PDF]

, 2016
The use of contrast-enhanced ultrasound (CEUS) in adults is well established in many different areas, with a number of current applications deemed off-label, but the use supported by clinical experience and evidence.
Cantisani, Vito, Deganello, A., Dietrich, C. F., Duran, C., Franke, D., Gilja, O. H., Harkanyi, Z., Kosiak, W., Miele, Vittorio, Ntoulia, A., Piskunowicz, M., Sellars, M. E., Sidhu, P. S   +12 more
core   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, EarlyView.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Management of pancreatic trauma

Journal of Visceral Surgery, 2016
Pancreatic trauma (PT) is associated with high morbidity and mortality; the therapeutic options remain debated.Retrospective study of PT treated in the University Hospital of Grenoble over a 22-year span. The decision for initial laparotomy depended on hemodynamic status as well as on associated lesions.
Girard, Edouard, Abba, J., Arvieux, C., Trilling, B., Sage, P.Y., Mougin, N., Perou, S., Lavagne, P., Létoublon, C.   +8 more
openaire   +3 more sources

Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]

, 2015
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi, Arne Holmgren, Chan PH, Chen EP, Chu FF, Daiber A, Elias S. J. Arnér, Geismann C, Hogan B, Jaarsma D, Jian-Hong Zhu, Jin R, Leitzmann C, Li JJ, Li JJ, Lu YP, Makino N, Miranda-Vizuete A, Mirochnitchenko O, Motoori S, Mulder DW, Ogata M, Oury TD, Papaioannou V, Radi R, Sandbach JM, Takahara S, Thimmulappa RK, Tome ME, Vogel U, Wang F, Wen JK, Wen-Hsing Cheng, Wispe JR, Woychik RP, Xin Gen Lei, Ye-Shih Ho, Yongping Bao, Yoshida T   +38 more
core   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Initial suction drainage decreases severe postoperative complications after pancreatic trauma: A cohort study. [PDF]

World J Gastrointest Surg, 2023
Li KW, Wang K, Hu YP, Yang C, Deng YX, Wang XY, Liu YX, Li WQ, Ding WW.   +8 more
europepmc   +1 more source

Fellowship training in Acute Care Surgery: from inception to current state. [PDF]

, 2016
Recognizing the need for urgent and emergent surgical care across America, the American Association for the Surgery of Trauma developed and implemented, and oversees, the Acute Care Surgery Fellowship Training Program.
Davis, Kimberly, Jurkovich, Gregory
core   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Delayed Presentation of Isolated Complete Pancreatic Transection as a Result of Sport-Related Blunt Trauma to the Abdomen

Case Reports in Gastroenterology, 2008
Introduction: Blunt abdominal trauma is a rare but well-recognized cause of pancreatic transection. A delayed presentation of pancreatic fracture following sport-related blunt trauma with the coexisting diagnostic pitfalls is presented. Case Report: A 17-
Andrew J. Healey, Ioannis Dimarakis, Madhava Pai, Long R. Jiao   +3 more
doaj   +1 more source