Results 211 to 220 of about 552,612 (348)

Inhibition of tumor growth and induction of apoptosis by adeno associated virus mediated fragile histidine triade (FHIT) gene overexpression in pancreatic cancer cell lines

, 2000
Kristoffel R. Dumon, Fatima Chakrani, Mathew J. During, Ernest F. Rosato, Noel N. Williams, Carlo C. Croce   +5 more
openalex   +1 more source

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

Corrigendum: The role of microtubules in pancreatic cancer: therapeutic progress

Frontiers in Oncology
Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Mugahed Abdullah Hasan Albahde, Bulat Abdrakhimov, Guo-Qi Li, Guo-Qi Li, Xiaohu Zhou, Xiaohu Zhou, Dongkai Zhou, Dongkai Zhou, Hao Xu, Hao Xu, Huixiao Qian, Huixiao Qian, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang, Weilin Wang   +19 more
doaj   +1 more source

Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations. [PDF]

Front Med (Lausanne)
Keepers Z, Sharma A, Roy S, Ryan H, Bhandary B, Ren L, Lamichhane N, Shukla HD.   +7 more
europepmc   +1 more source

Nab-Paclitaxel Plus Gemcitabine Vs Gemcitabine Alone for Patients with Metastatic Pancreatic Cancer: Influence of Primary Pancreatic Tumor Location on Efficacy and Treatment Exposure in the Mpact Phase III Trial [PDF]

, 2014
Lopez-Martin Jose, Ma Wen Wee, Christos S. Karapetis, Peter Balcke, Kennecke Hagan, Stahl Michael, Michèle Milella, Nugent Francis, Diane Prager, Brian Lu, Stefano Ferrara, Penenberg Darryl, Von Hoff Daniel   +12 more
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. [PDF]

Cell Death Differ
Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ.   +8 more
europepmc   +1 more source

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source

miR-96-5p-mediated Inhibition of CD47 contributes to pancreatic tumor regression via activating both innate and adaptive anti-tumor immunity. [PDF]

Cell Commun Signal
Tong S, Hua S, Wu Y, Xiao X, Leng Y, Wang Y, Sun M, Li J, Ou X, Zhao W, Wang L, Wang Y, Tan S.   +12 more
europepmc   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source