Results 231 to 240 of about 1,861,984 (306)

Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report. [PDF]

Future Sci OA
Slama E, Ben Hamida S, Zaouga S, Elloumi H, Cheikh I, Dahak AG, Missaoui M, Chelibi A, Ganzoui I.   +8 more
europepmc   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts. [PDF]

Sci Rep
Chiang S, Garcia Netto K, Kokkinos J, Haghighi KS, Raina AS, Youkhana J, Pitiyarachchi O, Truong Q, Wenholz D, Wilkinson J, Laczka O, Li X, Aldilla VR, Kumar N, Goldstein D, Sharbeen G, Phillips PA.   +16 more
europepmc   +1 more source

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

Evaluation of daily residual pancreatic tumor motion for deep-inspiration breath-hold radiotherapy. [PDF]

J Appl Clin Med Phys
Mao W, Wu B, Ding K, Han-Oh S, Narang A.
europepmc   +1 more source

SpaCut: Transcript‐Aware Morphology Fusion for Robust Cell Segmentation in Subcellular Spatial Transcriptomics

Advanced Science, EarlyView.
Subcellular spatial transcriptomics enables high‐resolution mapping of gene expression within tissues, but accurate cell segmentation is essential for assigning transcripts to individual cells. We present SpaCut, a deep learning framework that integrates transcriptomic features with nucleus‐guided morphological information to precisely delineate cell ...
Yongheng Li, Fangfang Zhu, Wenwen Min
wiley   +1 more source

SMF-net: semantic-guided multimodal fusion network for precise pancreatic tumor segmentation in medical CT image. [PDF]

Front Oncol
Zhou W, Shi Z, Xie B, Li F, Yin J, Zhang Y, Hu L, Li L, Yan Y, Wei X, Hu Z, Luo Z, Peng W, Xie X, Long X.   +14 more
europepmc   +1 more source

CaMKIIδ Phosphorylates AUP1 to Promote Pancreatic Tissue Repair and Acinar‐to‐Ductal Metaplasia Formation via Mediating PERK‐Dependent Unfolded Protein Responses

Advanced Science, EarlyView.
CaMKIIδ–AUP1 signaling maintains PERK‐dependent ER homeostasis during ADM‐mediated pancreatic repair. ABSTRACT Pancreatic repair after acute pancreatitis (AP) is essential for restoring tissue integrity, but the intrinsic mechanisms coordinating acinar plasticity and regeneration remain poorly understood.
Yonghao Chen, Ziying Han, Zihan Yang, Jie Wu, Kaixin Peng, Xiuli Zhang, Bintao Qiu, Jianqiang Wu, Xiaomin Hu, Dong Wu, Li Wen   +10 more
wiley   +1 more source

Identification of a senescence-associated transcriptional program in skeletal muscle of cachectic pancreatic-tumor-bearing mice. [PDF]

Am J Physiol Cell Physiol
Ducharme JB, Carelock ME, Schonk MM, Al-Zaeed NM, Zhang W, Judge SM, Judge AR.   +6 more
europepmc   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source