Results 211 to 220 of about 1,861,984 (306)

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Erratum: Diffusion MRI biomarkers predict the outcome of irreversible electroporation in a pancreatic tumor mouse model. [PDF]

Am J Cancer Res
Figini M, Wang X, Lyu T, Su Z, Wang B, Sun C, Shangguan J, Pan L, Zhou K, Ma Q, Yaghmai V, Procissi D, Larson AC, Zhang Z.   +13 more
europepmc   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations. [PDF]

Front Med (Lausanne)
Keepers Z, Sharma A, Roy S, Ryan H, Bhandary B, Ren L, Lamichhane N, Shukla HD.   +7 more
europepmc   +1 more source

Epithelial SLC25A20 Deficiency Drives Immunosuppressive Neutrophil Remodeling via ARG1 Palmitoylation to Promote Colorectal Cancer

Advanced Science, EarlyView.
SLC25A20 deficiency in tumor cells compromises mitochondrial LCFA transport, which suppresses FAO and drives compensatory release of palmitic acid‐enriched lipids into the TME. These tumor‐derived palmitic acids are taken up by TANs, promoting ZDHHC18‐catalyzed ARG1 palmitoylation.
Yue Han, Tian‐Yuan Tan, Bin Zhang, Ye‐Bin Fu, Wen Chen, Min‐Hui Yang, Yi‐Qing Wang, Yan‐Qing Ding, Shuang Wang   +8 more
wiley   +1 more source

Uncertainty-guided pancreatic tumor auto-segmentation with Tversky ensemble. [PDF]

Phys Imaging Radiat Oncol
Yu C, Gay SS, Gupta AC, Martin-Paulpeter RM, Ludmir EB, Zhao Y, Duryea J, Chen X, Cardenas CE, Yang J, Koong AC, Netherton TJ, Rhee DJ, Court LE.   +13 more
europepmc   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Correction to: The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. [PDF]

Cell Death Differ
Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ.   +8 more
europepmc   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Microbiological colonization of the pancreatic tumor affects postoperative complications and outcome after pancreatic surgery. [PDF]

Front Cell Infect Microbiol
Biesel EA, Sundheimer J, Badr MT, Posadas-Cantera S, Chikhladze S, Fichtner-Feigl S, Wittel UA.   +6 more
europepmc   +1 more source