Results 211 to 220 of about 1,718,006 (300)

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

Folate- and aCD47-functionalized lipid nanoparticles efficiently deliver mRNA and remodel pancreatic tumor microenvironment.

Biomed Pharmacother
Parés M, Martínez-Latorre J, Candela-Noguera V, Soriano-Teruel PM, García-Fernández A, Pallaruelo-Santamaría V, Aznar E, Martínez-Máñez R, Fillat C.   +8 more
europepmc   +1 more source

Challenges and Opportunities in Targeting the Complex Pancreatic Tumor Microenvironment. [PDF]

JCO Oncol Adv
Finan JM, Guo Y, Goodyear SM, Brody JR.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

CRO-67 has anti-cancer activity in pancreatic tumor cells and stromal cancer-associated fibroblasts. [PDF]

Sci Rep
Chiang S, Garcia Netto K, Kokkinos J, Haghighi KS, Raina AS, Youkhana J, Pitiyarachchi O, Truong Q, Wenholz D, Wilkinson J, Laczka O, Li X, Aldilla VR, Kumar N, Goldstein D, Sharbeen G, Phillips PA.   +16 more
europepmc   +1 more source

Primary adenocarcinoma of duodenal bulb mimicking a pancreatic tumor: a case report. [PDF]

Future Sci OA
Slama E, Ben Hamida S, Zaouga S, Elloumi H, Cheikh I, Dahak AG, Missaoui M, Chelibi A, Ganzoui I.   +8 more
europepmc   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

Advanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li, Yifei Cao, Jiaxin Lin, Huayong Yang, Hongzhao Zhou   +4 more
wiley   +1 more source

SMF-net: semantic-guided multimodal fusion network for precise pancreatic tumor segmentation in medical CT image. [PDF]

Front Oncol
Zhou W, Shi Z, Xie B, Li F, Yin J, Zhang Y, Hu L, Li L, Yan Y, Wei X, Hu Z, Luo Z, Peng W, Xie X, Long X.   +14 more
europepmc   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Evaluation of daily residual pancreatic tumor motion for deep-inspiration breath-hold radiotherapy. [PDF]

J Appl Clin Med Phys
Mao W, Wu B, Ding K, Han-Oh S, Narang A.
europepmc   +1 more source