Results 221 to 230 of about 1,861,984 (306)

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

miR-96-5p-mediated Inhibition of CD47 contributes to pancreatic tumor regression via activating both innate and adaptive anti-tumor immunity. [PDF]

Cell Commun Signal
Tong S, Hua S, Wu Y, Xiao X, Leng Y, Wang Y, Sun M, Li J, Ou X, Zhao W, Wang L, Wang Y, Tan S.   +12 more
europepmc   +1 more source

CRISPR‐Scan: Cas13a Mismatch Tolerance Enabled Ultra‐Multiplexed Detection of Same‐Site Indels in Acute Myeloid Leukemia

Advanced Science, EarlyView.
Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai, Bei Wang, Mingmin Shi, Dianwei Liu, Huimin Ji, Ting Wang, Ziwei Wang, Kaiming Guo, Xinyang Dou, Chunyan Qian, Fang Zhang, Yongming Wang, Hongju Mao, Rui Wang   +13 more
wiley   +1 more source

Challenges and Opportunities in Targeting the Complex Pancreatic Tumor Microenvironment. [PDF]

JCO Oncol Adv
Finan JM, Guo Y, Goodyear SM, Brody JR.
europepmc   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor. [PDF]

PLoS One
Suzuki Y, Sugimori M, Kanemaru Y, Onodera S, Tsuchiya H, Ikeda A, Ikeda R, Goda Y, Kaneko H, Irie K, Sue S, Ijichi H, Maeda S.   +12 more
europepmc   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Folate- and aCD47-functionalized lipid nanoparticles efficiently deliver mRNA and remodel pancreatic tumor microenvironment.

Biomed Pharmacother
Parés M, Martínez-Latorre J, Candela-Noguera V, Soriano-Teruel PM, García-Fernández A, Pallaruelo-Santamaría V, Aznar E, Martínez-Máñez R, Fillat C.   +8 more
europepmc   +1 more source

Refining antibiotic cocktail regimens for pseudo-germ-free mice and their impact on gut microbiome and pancreatic tumor proteomics. [PDF]

J Adv Res
Panyod S, Wu WK, Lee YP, Lin TY, Kuo PC, Yen CS, Chen YH, Chuang HL, Lo IH, Yang YT, Lo YL, Liao WT, Chen CT, Chow LP, Lin CH, Lee YC, Hsu CC, Wu MS.   +17 more
europepmc   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source