Results 41 to 50 of about 451,014 (336)

What should be measured and reported in clinical trials for the treatment of patients with acute pancreatitis? A study protocol for establishing a core outcome set

BMJ Open, 2023
Introduction Acute pancreatitis (AP) is characterised by inflammation of the exocrine pancreas, which potentially leads to local complications and organ failure resulting in significant morbidity and mortality.
Wei Huang, Ling Li, Xin Sun, Chen Hu, Lihui Deng, Ping Zhu, Qing Xia, Weiwei Chen, Yuxin Shen, Zhiyao Chen, Ziqi Lin, Qingyuan Tan   +11 more
doaj   +1 more source

The Diagnosis and Treatment of Local Complications of Acute Necrotizing Pancreatitis in China: A National Survey

Gastroenterology Research and Practice, 2021
Background. The optimal management strategy in acute necrotizing pancreatitis (ANP) is debated, and compliance with current guidelines in China is not known. In this study, we performed a national survey on this topic in China. Methods.
Xiaowu Dong, Wenjian Mao, Lu Ke, Lin Gao, Jing Zhou, Bo Ye, Gang Li, Anthony Phillips, Zhihui Tong, John Windsor, Weiqin Li, Chinese Acute Pancreatitis Clinical Trials Group (CAPCTG)   +11 more
doaj   +1 more source

Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. [PDF]

, 2012
Pancreatic duct glands (PDGs) have been hypothesized to give rise to pancreatic intraepithelial neoplasia (PanIN). Treatment with the glucagon-like peptide (GLP)-1 analog, exendin-4, for 12 weeks induced the expansion of PDGs with mucinous metaplasia and
Butler, Peter C, Dawson, David, Dry, Sarah M, Gier, Belinda, Kirakossian, David, Matveyenko, Aleksey V   +5 more
core   +1 more source

Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis—A Literature Review

Biomolecules
Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden.
Valborg Vang Poulsen, Amer Hadi, Mikkel Parsberg Werge, John Gásdal Karstensen, Srdan Novovic   +4 more
doaj   +1 more source

Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Frontiers in Medicine, 2021
Background: Pain management is an important priority in the treatment of acute pancreatitis (AP). Current evidence and guideline recommendations are inconsistent on the most effective analgesic protocol.
Wenhao Cai, Wenhao Cai, Fei Liu, Yongjian Wen, Chenxia Han, Manya Prasad, Qing Xia, Vikesh K. Singh, Robert Sutton, Wei Huang   +9 more
doaj   +1 more source

Diagnosis of pancreatic disease in feline platynosomosis [PDF]

, 2017
Objectives: Platynosomum species are cat-specific parasitic trematodes that parasitize the biliary ducts and gall bladder. Due to the common connection to the major duodenal papilla of the pancreas and common bile ducts in addition to the periductal ...
Illanes, Oscar, Ketzis, Jennifer, Köster, Liza, Rajeev, Sreekumari, Shell, Linda   +4 more
core   +1 more source

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.

Journal of Clinical Investigation, 2020
Elevated pressure in the pancreatic gland is the central cause of pancreatitis following abdominal trauma, surgery, endoscopic retrograde cholangiopancreatography (ERCP), and gallstones.
Sandip M. Swain, J. Romac, Rafiq A. Shahid, S. Pandol, W. Liedtke, Steven R Vigna, R. Liddle   +6 more
semanticscholar   +1 more source

Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway

Frontiers in Pharmacology, 2022
Obesity-related acute pancreatitis (AP) is characterized by increasing prevalence worldwide and worse clinical outcomes compared to AP of other etiologies.
Xinmin Yang, Linbo Yao, Mei Yuan, Xiaoying Zhang, Monika A. Jakubowska, Pawel E. Ferdek, Lei Dai, Jingyu Yang, Tao Jin, Lihui Deng, Xianghui Fu, Dan Du, Tingting Liu, David N. Criddle, Robert Sutton, Wei Huang, Wei Huang, Qing Xia   +17 more
doaj   +1 more source

Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute pancreatitis

Frontiers in Endocrinology, 2022
BackgroundTo determine the impact of glucose levels at admission and during first week (early phase) on clinical outcomes in patients with acute pancreatitis (AP) and to investigate the relationship between stress hyperglycaemia (SHG) and ...
Xinmin Yang, Na Shi, Linbo Yao, Wenhua He, Ping Zhu, Sheyu Li, Sheyu Li, Lan Li, Yuying Li, Shiyu Liu, Lihui Deng, Tao Jin, Tingting Liu, Nonghua Lu, John A. Windsor, Robert Sutton, Yin Zhu, Qing Xia, Wei Huang   +18 more
doaj   +1 more source

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. [PDF]

, 2015
Chronic pancreatitis (CP) is a progressive and irreversible inflammatory and fibrotic disease with no cure. Unlike acute pancreatitis (AP), we find that alternatively activated macrophages (AAMs) are dominant in mouse and human CP.
Chawla, Ajay, Habtezion, Aida, Hsieh, Michael H, Murali, Ramachandran, Pandol, Stephen J, Sharma, Vishal, Xue, Jing   +6 more
core   +2 more sources