Results 51 to 60 of about 454,560 (254)

Factors Influencing Physicians Migration—A Case Study from Romania

Mathematics, 2022
Brain drain is a phenomenon that, over time, has followed an upward trend. It is an important component represented by physicians’ migration. For the country of destination, the migration of physicians offers several advantages, whereas the country of ...
Simona Andreea Apostu, Valentina Vasile, Erika Marin, Elena Bunduchi   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Panel Regression of Arbitrarily Distributed Responses [PDF]

Journal of Data Science, 2021
The primary advantage of panel over cross-sectional regression stems from its control for the effects of omitted variables or "unobserved heterogeneity". However, panel regression is based on the strong assump- tions that measurement errors are independently identically ( i.i.d.) and normal.
openaire   +1 more source

What Financial Markets in the CEE Region Tell Us about Inflation Expectations [PDF]

Statistika: Statistics and Economy Journal
Inflation expectations have become a significant concern for monetary policy settings in the CEE region due to the sharp rise in inflation. The absence of market-based inflation expectations complicates the assessment of anchoring inflation expectations ...
František Táborský
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Does Financial Development Drive Entrepreneurship in Africa? A Panel Data Analysis

Managing Global Transitions
Entrepreneurship in Africa faces a multitude of challenges, with financial issues being prominently discussed in scholarly literature. Thus, this study explores how financial development plays a crucial role in encouraging entrepreneurship in Africa ...
Afees Oluwashina Noah, David Oladipo Olalekan   +1 more
doaj   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Panel smooth transition regression models [PDF]

, 2005
We develop a non-dynamic panel smooth transition regression model with fixed individual effects. The model is useful for describing heterogenous panels, with regression coefficients that vary across individuals and over time. Heterogeneity is allowed for by assuming that these coefficients are continuous functions of an observable variable through a ...
Andres Gonzalez, Timo Terasvirta, Dick van Dijk   +2 more
openaire   +6 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On the Estimation of Panel Regression Models with Fixed Effects [PDF]

SSRN Electronic Journal, 2002
This paper considers estimation of panel data models with fixed effects. First, we will show that a consistent "unrestricted fixed effects" estimator does not exist for autoregressive panel data models with initial conditions. We will derive necessary and sufficient conditions for the consistency of estimators for these models.
openaire   +2 more sources