Results 11 to 20 of about 22,431 (234)

Evaluation of nanobody-based biologics targeting purinergic checkpoints in tumor models in vivo

Frontiers in Immunology, 2022
Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor.
Mélanie Demeules, Allan Scarpitta, Romain Hardet, Henri Gondé, Catalina Abad, Marine Blandin, Stephan Menzel, Stephan Menzel, Stephan Menzel, Yinghui Duan, Björn Rissiek, Tim Magnus, Anna Marei Mann, Friedrich Koch-Nolte, Sahil Adriouch   +14 more
doaj   +1 more source

Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches

Stem Cell Research & Therapy, 2018
Background Canine MuStem cells have demonstrated regenerative efficacy in a dog model of muscular dystrophy, and the recent characterization of human counterparts (hMuStem) has highlighted the therapeutic potential of this muscle-derived stem cell ...
Charlotte Saury, Aurélie Lardenois, Cindy Schleder, Isabelle Leroux, Blandine Lieubeau, Laurent David, Marine Charrier, Laëtitia Guével, Sabrina Viau, Bruno Delorme, Karl Rouger   +10 more
doaj   +1 more source

Protecting Florida Panthers by Protecting Domestic Animals: Building a "Panther-Proof" Pen

EDIS, 2016
Florida panthers once ranged throughout most of the southeastern United States, but loss of habitat and efforts to eradicate panthers during the 1800s led to a large decline throughout much of their historic range.
Phillip D. Rodgers, Elizabeth F. Pienaar, Mark Lotz, Darrell Land   +3 more
doaj   +5 more sources

¿Vio un puma?

EDIS
Los pumas a veces se pueden confundir con gatos monteses, perros y coyotes. En este documento se proporcionan datos e imágenes que pueden ayudar a cualquier persona a identificar a un puma.
Diane J. Episcopio, Elizabeth F. Pienaar, Martin B. Main, Alejandra Areingdale, Armando Ubeda   +4 more
doaj   +3 more sources

Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

Journal of Neuroinflammation, 2019
Background Orexins (hypocretins, Hcrt) A and B are GPCR-binding hypothalamic neuropeptides known to regulate sleep/wake states and feeding behavior.
Laurine Becquet, Catalina Abad, Mathilde Leclercq, Camille Miel, Laetitia Jean, Gaëtan Riou, Alain Couvineau, Olivier Boyer, Yossan-Var Tan   +8 more
doaj   +1 more source

Assessment of adeno-associated virus gene therapies efficacy on acid alpha-glucosidase restoration and glycogen storage correction in cardiac muscle of Pompe disease mice using synchrotron infrared and ultraviolet microspectroscopies

Journal of Spectral Imaging, 2019
Pompe disease (glycogen storage disease type II) is a lysosomal storage disorder due to a mutation in the gene that encodes acid alpha-glucosidase (GAA).
Laurence Dubreil, Lydie Lagalice, Johan Deniaud, Antoine Sabourin, Claire Lovo, Karim Bey, Juliette Hordeaux, Chantal Thorin, Christophe Sandt, Frédéric Jamme, Marie-Anne Colle   +10 more
doaj   +1 more source

Long-term neurologic and cardiac correction by intrathecal gene therapy in Pompe disease

Acta Neuropathologica Communications, 2017
Pompe disease is a lysosomal storage disorder caused by acid-α-glucosidase (GAA) deficiency, leading to glycogen storage. The disease manifests as a fatal cardiomyopathy in infantile form.
J. Hordeaux, L. Dubreil, C. Robveille, J. Deniaud, Q. Pascal, B. Dequéant, J. Pailloux, L. Lagalice, M. Ledevin, C. Babarit, P. Costiou, F. Jamme, M. Fusellier, Y. Mallem, C. Ciron, C. Huchet, C. Caillaud, M-A Colle   +17 more
doaj   +1 more source

A Conservation-Based Approach to Compensation for Livestock Depredation: The Florida Panther Case Study. [PDF]

PLoS ONE, 2015
Calf (Bos taurus) depredation by the federally endangered Florida panther (Puma concolor coryi) on ranches in southwest Florida is an important issue because ranches represent mixed landscapes that provide habitat critical to panther recovery.
Caitlin E Jacobs, Martin B Main
doaj   +1 more source

Location and extent of unoccupied panther (Puma concolor coryi) habitat in Florida: Opportunities for recovery

Global Ecology and Conservation, 2021
Breeding Florida panthers (Puma concolor coryi) are currently restricted to a small area in southwest Florida south of the Caloosahatchee River. Expansion of their range and numbers is necessary for long-term survival and recovery.
Robert A. Frakes, Marilyn L. Knight
doaj   +1 more source

The Devil’s Threat in Medieval Bestiaries: Recognizing and Resisting Evil in the Dragon, Serpent, Wolf, Fox, Ape, Whale, Hawk, Partridge, and Raven

Ítaca
To medieval contemplatives, the devil posed a clear spiritual threat to those seeking to be piously devoted to Jesus. To avoid the plotting of the devil, monastics were advised to pray and study the scriptures.
Jane Beal
doaj   +1 more source