Results 31 to 40 of about 22,431 (234)

ASC nanobodies to counteract the consequences of inflammasome activation

EMBO Molecular Medicine, 2022
Inflammasomes are multiprotein complexes that signal by oligomerizing the apoptosis speck‐like protein with caspase recruitment and activator domain (ASC) and are involved in multiple inflammatory, metabolic and degenerative diseases.
Sahil Adriouch, Pablo Pelegrin
doaj   +1 more source

Asymmetry in Skipping Enhances Viability Against Control Input Noise

Advanced Robotics Research, EarlyView.
Quadruped animals use asymmetric galloping gaits at high speeds, yet the functional role of this asymmetry remains unclear. This study shows that left–right asymmetry in touchdown angles enhances robustness to control noise. Using a simple two‐legged locomotion model and viability theory, it demonstrates that asymmetric skipping substantially enlarges ...
Yuichi Ambe, Alvin So, Shinya Aoi
wiley   +1 more source

Risk and residency influences on public support for florida panther recovery

Wildlife Society Bulletin, 2012
Human expansion into core habitat of the Florida panther (Puma concolor coryi) increasingly threatens this endangered carnivore. To understand the social dimensions of the influence of humans' proximity to risk from panthers on public support for panther
Cynthia Langin, Susan K. Jacobson
doaj   +1 more source

Modeling the potential spread of the recently identified non-native panther grouper (Chromileptes altivelis) in the Atlantic using a cellular automaton approach. [PDF]

PLoS ONE, 2013
The Indo-pacific panther grouper (Chromileptes altiveli) is a predatory fish species and popular imported aquarium fish in the United States which has been recently documented residing in western Atlantic waters.
Matthew W Johnston, Sam J Purkis
doaj   +1 more source

Mixed muco-cutaneous pemphigoid: Clinical and immunological features of 15 cases

Frontiers in Immunology, 2023
IntroductionWe describe a series of patients whose auto-immune bullous skin disease (AIBD) of the dermal-epidermal junction (DEJ) was characterized by clinical, immunological and ultrastructural features intermediate between bullous pemphigoid (BP) and ...
Raphaël Janela, Norito Ishii, Marion Castel, Fabienne Jouen, Lucie Cellier, Philippe Courville, Pascal Joly, Pascal Joly, Vivien Hébert, Vivien Hébert   +9 more
doaj   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Verification of dried blood spot as a sample type for HIV viral load and early infant diagnosis on Hologic Panther in Zambia

BMC Research Notes, 2023
Objective Zambia has embarked on improving the diagnostic capacity by setting up high throughput and accurate machines in the testing process and introduction of dried blood spot (DBS) as a sample type.
Precious Simushi, Mukoshya Nchima Kalunga, Tuku Mwakyoma, Mulenga Mwewa, Lweendo Muchaili, Nchimunya Hazeemba, Chileshe Mulenga, Patience Mwewa, Kaseya O. R. Chiyenu, John Kachimba, Powell Choonga, Aaron Shibemba, Benison M. Hamooya, Mowa Zambwe, Peter J. Chipimo, Lackson Kasonka   +15 more
doaj   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Administration of an AAV vector coding for a P2X7-blocking nanobody-based biologic ameliorates colitis in mice

Journal of Nanobiotechnology
Background The pro-inflammatory ATP-gated P2X7 receptor is widely expressed by immune and non-immune cells. Nanobodies targeting P2X7, with potentiating or antagonistic effects, have been developed.
Catalina Abad, Mélanie Demeules, Charlotte Guillou, Henri Gondé, Rachid Zoubairi, Yossan-Var Tan, Carolina Pinto-Espinoza, Waldemar Schäfer, Anna Marei Mann, Valérie Vouret-Craviari, Friedrich Koch-Nolte, Sahil Adriouch   +11 more
doaj   +1 more source