Results 41 to 50 of about 6,825 (177)

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated. [PDF]

PLoS ONE, 2013
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization.
Christina Spry, Cristiano Macuamule, Zhiyang Lin, Kristopher G Virga, Richard E Lee, Erick Strauss, Kevin J Saliba   +6 more
doaj   +1 more source

Compartmentalization of Mammalian Pantothenate Kinases

PLoS ONE, 2012
The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) biosynthesis and regulate the amount of CoA in tissues by differential isoform expression and allosteric interaction with metabolic ligands. The four human and mouse PanK proteins share a homologous carboxy-terminal catalytic domain, but differ in their ...
Adolfo Alfonso-Pecchio, Matthew Garcia, Roberta Leonardi, Suzanne Jackowski   +3 more
openaire   +4 more sources

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

Haematologica, 2011
Deferiprone was shown to reverse iron deposition in Friedreich’s ataxia. This multi-center, unblinded, single-arm pilot study evaluated safety and efficacy of deferiprone for reducing cerebral iron accumulation in neurodegeneration with brain iron ...
Giovanni Abbruzzese, Giovanni Cossu, Manuela Balocco, Roberta Marchese, Daniela Murgia, Maurizio Melis, Renzo Galanello, Susanna Barella, Gildo Matta, Uberto Ruffinengo, Ubaldo Bonuccelli, Gian Luca Forni   +11 more
doaj   +1 more source

Acanthocytosis and the c.680 A>G Mutation in the PANK2 Gene: A Study Enrolling a Cohort of PKAN Patients from the Dominican Republic. [PDF]

PLoS ONE, 2015
Pantothenate Kinase-Associated Neurodegeneration (PKAN) is a form of Neurodegeneration with Brain Iron Accumulation (NBIA) associated with mutations in the pantothenate kinase 2 gene (PANK2).
Jasmin Schiessl-Weyer, Pedro Roa, Franco Laccone, Britta Kluge, Alexander Tichy, Euripedes De Almeida Ribeiro, Rainer Prohaska, Peter Stoeter, Claudia Siegl, Ulrich Salzer   +9 more
doaj   +1 more source

A novel homozygous variation in the PANK2 gene in two Persian siblings with atypical pantothenate kinase associated neurodegeneration

Neurology International, 2019
Pantothenate Kinase-associated Neurodegeneration (PKAN) is an autosomal recessive disorder that is caused by variation in pantothenate kinase-2 gene (PANK2) gene on chromosome 20.
Amir Hasan Habibi, Saeed Razmeh, Omid Aryani, Mohammad Rohani, Laleh Taghavian, Elham Alizadeh, Karim Moradian Kokhedan, Maryam Zaribafian   +7 more
doaj   +1 more source

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation [PDF]

, 2019
Neurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders in which iron accumulates in the basal ganglia resulting in progressive dystonia, spasticity, parkinsonism, neuropsychiatric abnormalities, and optic ...
Cotán, David, Álvarez Córdoba, Mónica, Villalón García, Irene, Villanueva Paz, Marina, Talaverón Rey, Marta, Salas, Joaquín J., Díaz Quintana, Antonio Jesús, Pérez Villegas, Eva Mª, Armengol, José A., Pérez Pulido, Antonio J., Fernández Khoury, Aida, Suárez Rivero, Juan M., Sánchez Alcázar, José A., Povea Cabello, Suleva, Gómez Navarro, Carmen, Mata, Mario de la   +15 more
core   +1 more source

Novel PANK2 mutation identified in patient with pantothenate kinase-associated neurodegeneration [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2020
Introduction. Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, recessively inherited disorder caused by mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20p13.
Svetel Marina, Novaković Ivana, Tomić Svetlana, Kresojević Nikola, Kostić Vladimir   +4 more
doaj   +1 more source

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation [PDF]

, 2018
50 Páginas; 9 FigurasNeurodegeneration with brain iron accumulation (NBIA) is a group of inherited neurologic disorders in which iron accumulates in the basal ganglia resulting in progressive dystonia, spasticity, parkinsonism, neuropsychiatric ...
Suarez-Rivero, Juan M., Álvarez-Córdoba, Mónica, Cotán, David, Povea-Cabello, Suleva, Villanueva-Paz, Marina, Salas, Joaquín J., Fernández-Khoury, Aida, Armengol, José A., Talaverón-Rey, Marta, Díaz-Quintana, Antonio, Gómez-Navarro, Carmen, Villalón-García, Irene, Pérez-Villegas, Eva María, Sánchez-Alcázar, José Antonio, Mata, Mario de la   +14 more
core   +1 more source

Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration [PDF]

Journal of Biological Chemistry, 2006
The PANK2 gene encodes the human pantothenate kinase 2 protein isoforms, and PANK2 mutations are linked to pantothenate kinase-associated neurodegeneration. Two PanK2 protein forms are proteolytically processed to form a mitochondrially localized, mature PanK2.
Yong-Mei, Zhang, Charles O, Rock, Suzanne, Jackowski   +2 more
openaire   +2 more sources

Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories.

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
core   +1 more source