Results 111 to 120 of about 49,790 (302)

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Scheme of tongue papillae and foliate papillae

A. Circumvallate papillae (tongue, human, adult) magnification x 35 objective. B. Foliate papillae (tongue, rabbit) magnification x 85 objective. C. Taste bud in foliate papilla (tongue, rabbit) magnification x 750 objective. 1.
Poels, Lambert G.
core  

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Synergistic Integration of Artificial Merkel Disc and Meissner Corpuscle via Dermal Papillary Structures for Mechanically Filtered Multimodal Tactile Sensing

Advanced Science
Human skin efficiently perceives tactile stimuli through specialized mechanoreceptors strategically arranged around the papillary structure at the epidermis–dermis junction.
Jaehyeong Kim, Bohee Maeng, Seunghwan Seo, Kyoung‐Yong Chun, Chang‐Soo Han   +4 more
doaj   +1 more source

Tongue Papillae Scheme - tongue, human, adult

A. Scheme survey dorsal surface of tongue (human, adult). Magnification 35x. B. Scheme of filiform and fungiform papillae (tongue, human, adult). Magnification 35x. 1. foliate papillae (rudimentary in human); 2.
Poels, Lambert G.
core  

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Light and scanning microscopic structure of filiform papillae in mice. [PDF]

, 2006
Cilj istraživanja bio je istražiti svjetlosnu i »skening» elektronsku mikroskopsku strukturu nitastih bradavica u odrasla miša. Svjetlosnom mikroskopijom utvrđeno je da su bradavice prekrivene višeslojnim pločastim epitelom te da osnovu čini vezivno ...
Toprak, Burhan, Burhan Toprak
core   +1 more source

Radical Resection of the Third Portion of the Duodenum for Secondary Aortoduodenal Fistula

Annals of Gastroenterological Surgery, EarlyView.
Secondary aortoduodenal fistula most commonly involves the third portion of the duodenum and requires definitive management of both vascular and gastrointestinal components. We demonstrate a step‐by‐step technique for radical duodenal resection and reconstruction performed in structured collaboration with cardiovascular surgeons.
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tatsuichiro Seto, Yuji Soejima   +4 more
wiley   +1 more source

Selaginella pectopuellensis (Selaginellaceae, Lycopodiophyta): a new species from Serra do Peito-de-Moça, Bahia, Brazil, with comments on the taxonomy of the species reported in the country

Boletín de la Sociedad Argentina de Botánica
Background and aims: Our research on neotropical Selaginella led us to examine a collection from the Atlantic Forest of Serra do Peito-de-Moça, Bahia, Brazil, initially determined as S.
Iván A. Valdespino, Christian A. López, Jorge I. Ceballos, José M. Palacios   +3 more
doaj   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source