Results 101 to 110 of about 30,861 (268)

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang   +16 more
wiley   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

open access: yesArthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald   +9 more
wiley   +1 more source

The peri-implant papilla: realities on papilla preservation and reformation.

open access: yesJournal of the California Dental Association, 2009
The purpose of this article is to provide clinicians with an understanding of the biologic parameters influencing peri-implant papilla preservation and reformation. The article reviews peri-implant papilla reconstruction techniques with emphasis on presurgical bone and soft tissue biotype assessment.
Doina, Panaite   +2 more
openaire   +1 more source

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad   +4 more
wiley   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

open access: yesBMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang   +13 more
wiley   +1 more source

Bilateral Symmetry and Variation of Recurrent Laryngeal Nerve and Inferior Thyroid Artery Patterns: An Intraoperative Study of 150 Nerves

open access: yesClinical Anatomy, EarlyView.
ABSTRACT The anatomical relationship of the inferior thyroid artery (ITA) and the recurrent laryngeal nerve (RLN) is highly variable. This study aims to evaluate bilateral RLN branching patterns and their relationship to the ITA within the same patient, predicting contralateral anatomical variations and ultimately reducing intraoperative risk of RLN ...
Mark Yanni   +3 more
wiley   +1 more source

Volumetric analysis of root coverage with porcine acellular dermal matrix: Case study

open access: yesClinical Advances in Periodontics, EarlyView.
Abstract Background Gingival recession is prevalent and often treated with coronally advanced flap plus connective tissue graft (CAF+CTG). Porcine acellular dermal matrix (PADM) offers a donor‐site‐free alternative. Contemporary digital imaging allows minimally invasive, three‐dimensional (3D) soft‐tissue assessment. This case report quantified 3D soft‐
Edgar Daniel Vargas‐Quiroga   +4 more
wiley   +1 more source

Effect of aesthetic crown lengthening on life quality and self‐esteem: 2‐year study

open access: yesClinical Advances in Periodontics, EarlyView.
Abstract Background A gummy smile can result from several factors, often leading to a disharmonious appearance and causing physical and psychological discomfort for the patient. This study aimed to evaluate changes in self‐esteem and quality of life for patients, as well as the recidivism rate, following aesthetic crown lengthening (ACL) surgery ...
Leticia S. Arroteia   +7 more
wiley   +1 more source

Modified coronally advanced flap for multiple anterior gingival recessions: Case report

open access: yesClinical Advances in Periodontics, EarlyView.
Abstract Background The frontal envelope coronally advanced flap (CAF), designed for multiple adjacent gingival recessions (MAGR) of the anterior maxilla, involves tunneling of the midline papilla. However, when treating frontal and lateral MAGR in a single session, the tunneled midline papilla can act as a fixed point, which may limit coronal ...
Kevimy Agossa   +3 more
wiley   +1 more source

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