Brain and Behavior, Volume 16, Issue 5, May 2026.Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah +7 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang +8 more
wiley +1 more source
Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracellular Permeability and Mucosal Homeostasis. [PDF]
Int J Mol Sci, 2020 He WQ +5 more
europepmc +1 more source
Octreotide Counteracts IFN‐γ‐Induced Endothelial Inflammation
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.ABSTRACT Endothelial cells maintain vascular homeostasis through the regulation of permeability and coagulation. Interferon‐gamma (IFN‐γ), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction.
Saikat Fakir +3 more
wiley +1 more source
Critical Review: The Past, Present, and Future of Small Intestinal Bacterial Overgrowth (SIBO)
JGH Open, Volume 10, Issue 5, May 2026.ABSTRACT Small intestinal bacterial overgrowth (SIBO) has evolved from a severe debilitating illness to a clinical spectrum associated with abnormalities of microbial populations in the small intestine. It is best described as a pathophysiological state that may contribute to symptoms or other pathology in a wide range of gastrointestinal conditions ...
Ayesha Shah +2 more
wiley +1 more source
Chitosan–Alginate Polyelectrolyte Systems: From Classical Release Models to the D‐PARMO Framework
Macromolecular Materials and Engineering, Volume 311, Issue 5, May 2026.Classical empirical models fail to predict the dynamic in vivo behavior of chitosan‐alginate nanocarriers. Bridging this translational gap, the novel D‐PARMO framework replaces purely descriptive curve‐fitting with a mechanistically informed operational model.
Parastoo Rekab, Akeem Adeyemi Oladipo
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Herb‐Based Extracellular Vesicles for Infectious Disease
Small Structures, Volume 7, Issue 5, May 2026.Chinese herbal medicine‐derived extracellular vesicles‐like particles (CHM‐EVLPs) are presented as innovative nanomedicines for infectious diseases. This review highlights their diverse therapeutic effects, including pathogen clearance, immune modulation, microbiota regulation and tissue barrier repairment, unlocking a powerful natural material against
Erjia Weng +13 more
wiley +1 more source
Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway. [PDF]
Mol Biol RepZhang M +8 more
europepmc +1 more source
Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik +3 more
wiley +1 more source
Antimicrobial activity of <i>Pediococcus pentosaceus</i> strains against diarrheal pathogens isolated from pigs and effect on paracellular permeability of HT-29 cells. [PDF]
J Anim Sci TechnolCho E, Yoo Y, Yoon Y.
europepmc +1 more source