Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management
Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz +3 more
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Innovative Drug Delivery Systems for the Treatment of Glaucoma
MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu +9 more
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Baicalin-Induced Autophagy Preserved LPS-Stimulated Intestinal Cells from Inflammation and Alterations of Paracellular Permeability. [PDF]
Int J Mol Sci, 2021 Rizzo V +8 more
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MedComm – Oncology, Volume 5, Issue 2, June 2026.This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
Solvent drag measurement of transcellular and basolateral membrane NaCl reflection coefficient in kidney proximal tubule. [PDF]
, 1991 The NaCl reflection coefficient in proximal tubule has important implications for the mechanisms of near isosmotic volume reabsorption. A new fluorescence method was developed and applied to measure the transepithelial (sigma NaClTE) and basolateral ...
Fushimi, K, Shi, LB, Verkman, AS
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Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini +7 more
wiley +1 more source
Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts [PDF]
, 2018 In the central nervous system (CNS) complex endothelial tight junctions (TJs) form a restrictive paracellular diffusion barrier, the blood-brain barrier (BBB).
Cecchelli, Roméo +8 more
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The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life. [PDF]
J Transl Med, 2021 Kaczmarczyk M +10 more
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British Journal of Pharmacology, Volume 183, Issue 12, Page 3213-3233, June 2026.Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud +9 more
wiley +1 more source
The Influence of Dissolved Organic Matter (DOM) on Sodium Regulation and Nitrogenous Waste Excretion in the Zebrafish (Danio rerio) [PDF]
, 2016 Dissolved organic matter (DOM) is both ubiquitous and diverse in composition in natural waters, but its effects on the branchial physiology of aquatic organisms have received little attention relative to other variables (e.g.
Al-Reasi, Hassan A. +2 more
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