Results 151 to 160 of about 328,971 (180)
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Tight junctions and the molecular basis for regulation of paracellular permeability
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995Tight junctions create a regulated paracellular barrier to the movement of water, solutes, and immune cells between both epithelial and endothelial cells. Recent progress has been made in identifying the proteins that create this barrier. The transmembrane protein occludin is an excellent candidate for the sealing protein and is bound on the ...
J M, Anderson, C M, Van Itallie
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Enhancing paracellular permeability by modulating epithelial tight junctions
Pharmaceutical Science & Technology Today, 2000The intestinal epithelium is a major barrier to the absorption of hydrophilic drugs. The presence of intercellular junctional complexes, particularly the tight junctions (zona occludens), renders the epithelium impervious to hydrophilic drugs, which cannot diffuse across the cells through the lipid bilayer of the cell membranes.
, Ward, , Tippin, , Thakker
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PERMEABILITY OF MYOCARDIAL CAPILLARIES TO HYDROPHILIC DRUGS: THE PARACELLULAR PATHWAY
Clinical and Experimental Pharmacology and Physiology, 1996SUMMARY1. As the majority of drug molecules are relatively small and lipophilic, capillary uptake in those regions with a continuous endothelium, such as the heart, has generally been regarded as taking place by flow‐limited transcellular capillary transport.
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Correlation of in vitro cytotoxicity with paracellular permeability in Caco-2 cells
Toxicology in Vitro, 2005This in vitro study aims to develop a cell culture model that compares paracellular permeability (PP) with acute cytotoxicity (AC). Caco-2 cells were seeded in 96-well plates and on polycarbonate filter inserts. Confluent monolayers were exposed to increasing concentrations of 20 reference chemicals for 24-h and 72-h.
Roula, Konsoula, Frank A, Barile
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Water permeability in the human amnion: pH regulation of the paracellular pathway
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1989Human amnion was mounted, immediately after delivery, as a diaphragm between two lucite chambers and the net transepithelial water movement (Jw) was recorded minute by minute. When Jw was plotted against the applied transepithelial hydrostatic pressure (fetal side positive), in the absence of any other gradient, a linear relationship was observed ...
M, Porta, C, Capurro, M, Parisi
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Protamine reversibly decreases paracellular cation permeability inNecturus gallbladder
The Journal of Membrane Biology, 1985Protamine, a naturally occurring arginine-rich polycationic protein (pI 9.7 to 12), was tested in Necturus gallbladder using a transepithelial AC-impedance technique. Protamine sulfate or hydrochloride (100 micrograms/ml = 20 microM), dissolved in the mucosal bath, increased transepithelial resistance by 89% without affecting the resistance of ...
M, Fromm +3 more
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ZO-1 and -2 Are Required for TRPV1-Modulated Paracellular Permeability
Journal of Dental Research, 2015The tight junction–based paracellular pathway plays an important role in saliva secretion. Zonula occludens (ZO) proteins are submembranous proteins of tight junction complex; however, their function in salivary epithelium is poorly understood. Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin ...
J, Li +11 more
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Cytoskeletal regulation of Caco‐2 intestinal monolayer paracellular permeability
Journal of Cellular Physiology, 1995AbstractAn abnormal increase in intestinal paracellular permeability may be an important pathogenic factor in various intestinal diseases. The intracellular factors and processes that regulate and cause alteration of intestinal paracellular permeability are not well understood.
T Y, Ma +5 more
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Cold exposure increases intestinal paracellular permeability to nutrients in the mouse
Journal of Experimental Biology, 2013Summary In situations of increased energy demand/food intake, animals can often acclimate within several days. The intestine generally responds to elevated digestive demand by increasing in size. However, there is likely a limit to how quickly the intestine can grow to meet the new demand.
Edwin R, Price +3 more
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Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland
Journal of Cell Science, 2013Summary Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia. We previously reported that activation of transient receptor potential vanilloid subtype 1 (TRPV1) in rabbit submandibular gland promoted salivary secretion, partly by an increase in paracellular permeability.
Xin, Cong +10 more
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