Results 141 to 150 of about 328,971 (180)

Regulation of paracellular permeability: factors and mechanisms

Molecular Biology Reports, 2013
Epithelial permeability is composed of transcellular permeability and paracellular permeability. Paracellular permeability is controlled by tight junctions (TJs). Claudins and occludin are two major transmembrane proteins in TJs, which directly determine the paracellular permeability to different ions or large molecules.
Wan-Xi Yang, Fu-Qing Tan, Yan-Jun Hu
exaly   +3 more sources

Multiple domains of occludin are involved in the regulation of paracellular permeability

Journal of Cellular Biochemistry, 2000
Tight junctions form selective paracellular diffusion barriers that regulate the diffusion of solutes across epithelia and constitute intramembrane diffusion barriers that prevent the intermixing of apical and basolateral lipids in the extracytoplasmic leaflet of the plasma membrane.
Karl Matter, Maria S Balda, Marcelino Cereijido   +2 more
exaly   +3 more sources

Modulation of epithelial and endothelial paracellular permeability by leukocytes

Advanced Drug Delivery Reviews, 2000
The tight junction acts as a regulated barrier for diffusion of ions, larger solutes, and migration of leukocytes through the paracellular space. Barrier function varies with the tissue type, and positively correlates with the number and complexity of tight junction strand formation.
Charles Parkos
exaly   +3 more sources

Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1992
Many hormones and drugs exert their effects on cells by increasing cytosolic Ca2+ (Cai2+) and activating protein kinase C (PKC). Each of these actions results in cholestasis in the isolated perfused rat liver, but the responsible mechanisms are unclear.
M H, Nathanson, A, Gautam, O C, Ng, R, Bruck, J L, Boyer   +4 more
openaire   +3 more sources

Endotoxin increases paracellular permeability of isolated rat hepatocyte couplets

Hepatology Research, 2001
Hyperbilirubinemia is frequently associated with endotoxemia. Regurgitation of bile constituents including bilirubin into the sinusoidal space is prevented by tight junctions which maintain paracellular permeability between hepatocytes. To investigate the mechanism of endotoxin-associated hyperbilirubinemia, we have studied the changes in paracellular ...
Hironori Koga, Masaru Harada, Shotaro Sakisaka   +2 more
exaly   +3 more sources

Barriers to paracellular permeability in rabbit esophageal epithelium

Gastroenterology, 1992
Morphological and electrophysiological techniques were used to define the location and nature of the barriers to diffusion across the intercellular space (paracellular pathway) of rabbit esophageal epithelium. Transmission electron microscopy and light microscopy coupled with histochemistry identified a series of tight junctions and an intercellular ...
R C, Orlando, E R, Lacy, N A, Tobey, K, Cowart   +3 more
openaire   +2 more sources

Modulation of intestinal paracellular permeability by intracellular mediators and cytoskeleton

Canadian Journal of Physiology and Pharmacology, 1997
The influence of cytoskeletal inhibitors (cytochalasin E and colchicine) and intracellular mediators (cAMP, Ca2+, and protein kinase C) in the control of paracellular permeability to mannitol has been examined in rat jejunum in Ussing-type chambers. Cytoskeletal inhibitors, cytochalasin E (20 mumol.L-1) or colchicine (0.5 mmol.L-1), when present in ...
M, Pérez, A, Barber, F, Ponz
openaire   +2 more sources

Nonelectrolyte permeability of the paracellular pathway in Necturus proximal tubule

American Journal of Physiology-Legacy Content, 1975
Micropuncture experiments were performed on Necturus proximal tubule using stationary microperfusion and microrecollection techniques. The transepithelial movement of the extracellular marker, sucrose, was used to investigate the passive permeability of the paracellular shunt pathway under steady-state conditions, during spontaneous reabsorption and ...
C A, Berry, E L, Boulpaep
openaire   +2 more sources

Modulation of Endothelial Paracellular Permeability

1992
Inflammatory edema is a significant element of many disease, e.g., adult respiratory distress syndrome, septicemia, and hypoxia/reperfusion syndrome. In vivo studies have sought to identify the mechanism(s) by which inflammatory mediators produce edema.
F. R. Haselton, J. S. Alexander, S. N. Mueller, A. P. Fishman   +3 more
openaire   +1 more source