Results 141 to 150 of about 41,666 (255)

Protective Effect of Limosilactobacillus fermentum ME-3 against the Increase in Paracellular Permeability Induced by Chemotherapy or Inflammatory Conditions in Caco-2 Cell Models. [PDF]

Int J Mol Sci, 2023
De Gregorio A, Serafino A, Krasnowska EK, Superti F, Di Fazio MR, Fuggetta MP, Hammarberg Ferri I, Fiorentini C.   +7 more
europepmc   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system. [PDF]

, 2019
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a vasodilator in 1970, has multiple physiological and pathological effects on development, growth, and the control of neuronal, epithelial, and endocrine cell functions ...
Akiba, Yasutada, Iwasaki, Mari, Kaunitz, Jonathan D   +2 more
core  

NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium. [PDF]

Int J Mol Sci, 2022
Ghim M, Yang SW, David KRZ, Eustaquio J, Warboys CM, Weinberg PD.   +5 more
europepmc   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice. [PDF]

Front Immunol, 2021
Zhang X, Monnoye M, Mariadassou M, Beguet-Crespel F, Lapaque N, Heberden C, Douard V.   +6 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes. [PDF]

Microscopy (Oxf), 2022
Ishikawa S, Nikaido M, Otani T, Ogata K, Iida H, Inai Y, Tamaoki S, Inai T.   +7 more
europepmc   +1 more source

Edulitin 2, a Ribotoxin‐Like Protein From Boletus edulis That Triggers Apoptosis in Colon Cancer Cells While Preserving the Integrity of the Intestinal Microbiota

eFood, Volume 7, Issue 3, June 2026.
Edulitin 2 is a ribotoxin‐like protein exhibiting a potent antiproliferative activity towards Caco‐2 and HT29 cells by programmed cell death. However, edulitin 2 does not affect gut microbiota growth, despite damaging fungal ribosomes. ABSTRACT Porcini (Boletus edulis Bull.) are a reservoir of pharmacological biomolecules with health‐promoting ...
Massimo Bortolotti, Sara Ragucci, Federica Falà, Anella Saggese, Francesco Biscotti, Ylenia De Luca, Nicola Landi, Paolo V. Pedone, Andrea Bolognesi, Ezio Ricca, Letizia Polito, Antimo Di Maro   +11 more
wiley   +1 more source

Ion permeability profiles of renal paracellular channel‐forming claudins

Acta Physiologica
Abstract Aim Members of the claudin protein family are the major constituents of tight junction strands and determine the permeability properties of the paracellular pathway. In the kidney, each nephron segment expresses a distinct subset of claudins that form either barriers against ...
Ioanna Pouyiourou, Anja Fromm, Jörg Piontek, Rita Rosenthal, Mikio Furuse, Dorothee Günzel   +5 more
openaire   +2 more sources