Results 101 to 110 of about 58,096 (266)
Acta Paediatrica, EarlyView.ABSTRACT Aim This study examined how parents perceive and experience point‐of‐care testing in a paediatric emergency department and how these tests relate to the overall diagnostic process. Parents sought care for their children due to suspected respiratory tract infections. Methods Twenty parents participated in semi‐structured interviews.
Helle Mølsted Alvesson +3 more
wiley +1 more source
Scandinavian Journal of Trauma, Resuscitation and Emergency MedicineBackground In this retrospective observational study, we compared the efficacy and safety of paracetamol compared with those of nalbuphine plus paracetamol and piritramide in prehospital analgesia for trauma-related pain administered by paramedics ...
Jonas Lohmann +12 more
doaj +1 more source
Alkalinised lidocaine as an anaesthetic before onabotulinumtoxinA injections. a randomised trial
BJU International, Volume 135, Issue 4, Page 638-647, April 2025.Objectives To evaluate the effect of intravesical alkalinised lidocaine as an anaesthetic treatment on procedural pain during intradetrusor onabotulinumtoxinA (BTX‐A) injections for overactive bladder. Patients and Methods This single‐centre, randomised, double‐blind, placebo‐controlled two period crossover trial was conducted on women scheduled for ...
Meryam El Issaoui +2 more
wiley +1 more source
Symptom‐guided reduction of BCG dwell time: findings from the north‐REG randomized trial
BJU International, EarlyView.Objectives To evaluate the impact of personalized dwell‐time (DT) reductions on symptom prevalence and systemic toxicities in patients undergoing Bacillus Calmette–Guérin (BCG) instillation for non‐muscle invasive bladder cancer (NMIBC). Methods Within a multinational randomized controlled trial (North‐REG Dwell Time Study [NCT04701151]), 225 patients ...
Lene Munk +15 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Clinical &Experimental Allergy, EarlyView.Global Asthma Network Phase I surveyed children, adolescents, and adults worldwide to assess the prevalence of asthma, rhinoconjunctivitis, and eczema. Human Development Index (HDI) and Gini inequality index (GinI) were important explanatory factors for prevalence variability of these conditions, with hotspots in areas with high HDI and high GinI ...
Luis García‐Marcos +15 more
wiley +1 more source
Effect of Hyaluronic Acid on Palatal Wound Healing—A Randomized Crossover Clinical Trial
Clinical Oral Implants Research, EarlyView.ABSTRACT Aim To assess the effect of a hyaluronic acid (HyA) containing gel on patient‐related outcomes (PRO) and wound healing after palatal punch‐biopsy representing a free gingival graft. Material and Methods A punch‐biopsy (6 mm diameter, 2 mm thickness) was harvested from one side of the palate at Day 0 and from the contralateral side at Day 21 ...
Madeleine Dahi +5 more
wiley +1 more source