Results 151 to 160 of about 93,899 (311)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

High Bleeding Rates After Tonsil Surgery in Denmark and Opportunities for Quality Improvement

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives To examine postoperative bleeding rates and associated patient and surgical factors after tonsil surgery in Denmark and identify targets for quality improvement. Design Multicentre cohort study using prospectively collected registry data.
Martin Mølhave, Nina M. Lyhne, Susanne H. Nielsen, Pernille Hahn, Jesper K. Holm, Therese Ovesen   +5 more
wiley   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Neuropathic pain in cerebral palsy and related genetic conditions: A scoping review of prevalence, characteristics, and management

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To map existing evidence on neuropathic pain in cerebral palsy (CP) and related genetic conditions, including prevalence, descriptors, assessment methods, and management. Method Following prospective registration, five databases (Ovid MEDLINE, Embase, CINAHL, Web of Science, Google Scholar) were searched in June 2025.
Aayushi Khillan, Sanya Verma, Hannah Yeomans, Karen Bau, Caitlin Doyle, Monica S. Cooper, David J. Amor, Carolyn Berryman, Adrienne Harvey   +8 more
wiley   +1 more source

Improving emergency care for sickle cell disease in Germany: Impact of a multimodal quality improvement initiative at a tertiary care centre

British Journal of Haematology, EarlyView.
Laura Distelmaier, Johannes C. Hellmuth, Matthias Klein, Markus Woernle, Joachim Stemmler, Marion Subklewe, Veit Buecklein, Karten Spiekermann, Oliver Weigert, Martin Dreyling, Julian Holch, Sebastian Theurich, Michael von Bergwelt‐Baildon, Sarah Haebe   +13 more
wiley   +1 more source

Prenatal exposure to paracetamol and the risk of autism and attention‐deficit/hyperactivity disorder: An umbrella review and meta‐meta‐analysis

Developmental Medicine &Child Neurology, EarlyView.
This meta‐meta‐analysis synthesizes evidence on prenatal paracetamol exposure and neurodevelopmental outcomes. Crude analyses suggest small associations with autism and ADHD, but these attenuate substantially when restricting to high‐quality meta‐analyses and low‐bias primary studies.
Hoda Tayebi‐Hillali, María Blanco‐Suárez, Berta Rivas‐Mundiña, Jacobo Limeres‐Posse, Márcio Diniz‐Freitas, Pedro Diz‐Dios   +5 more
wiley   +1 more source

Comparison of the postoperative analgesic effects of preemptive paracetamol, paracetamol-diclofenac and paracetamol-tramadol in patients undergoing elective abdominal surgery at a tertiary care hospital, Karachi

Objective: To compare the postoperative analgesic effects of preemptive paracetamol, paracetamol-diclofenac, and paracetamol-tramadol in patients undergoing elective abdominal surgery at a tertiary care hospital in Karachi.
Arqam Shaikh, Ashok Kumar, Javeriya Zahid, Siraj Ahmed   +3 more
core   +1 more source

¿Aumenta la exposición prenatal al paracetamol el riesgo de trastorno del espectro autista y trastorno por déficit de atención con hiperactividad? Una revisión paraguas y un meta‐meta‐análisis

Developmental Medicine &Child Neurology, EarlyView.
Este meta‐metaanálisis sintetiza la evidencia disponible sobre la exposición prenatal al paracetamol y los desenlaces del neurodesarrollo. Los análisis crudos sugieren pequeñas asociaciones con el trastorno del espectro autista (TEA) y el trastorno por déficit de atención e hiperactividad (TDAH); sin embargo, estas asociaciones se atenúan de forma ...
Hoda Tayebi‐Hillali, María Blanco‐Suárez, Berta Rivas‐Mundiña, Jacobo Limeres‐Posse, Márcio Diniz‐Freitas, Pedro Diz‐Dios   +5 more
wiley   +1 more source

PaSo paracetamol with strong opioids trial: paracetamol versus placebo in conjunction with strong opioids for cancer pain-a pilot randomised placebo-controlled withdrawal trial. [PDF]

BMJ Support Palliat Care
Hagen KMR, McWilliams K, Bowden J, Harvie K, Paulsen Ø, Fallon M.   +5 more
europepmc   +1 more source