Results 51 to 60 of about 6,588 (165)

Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Antimicrobial peptides (AMPs) are promising alternatives to conventional treatments for polymicrobial biofilms, which increase pathogen resistance. AMPs disrupt biofilm extracellular matrices and microbial membranes, inhibiting biofilm formation and enhancing antibiotic efficacy. Current research addresses challenges like stability and production costs
Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio   +11 more
wiley   +1 more source

Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early‐Stage Nonsmoking Lung Adenocarcinoma Patients

Thoracic Cancer, Volume 16, Issue 2, January 2025.
ES‐LUAD exhibits specific enrichment or depletion of certain fungal species, showing significant correlations with host transcription. Additionally, we have developed a fungal consortium that can effectively distinguish between patients with ES‐LUAD and HCs.
Yaohui Sun, Zhiming Gan, Shijiancong Liu, Sheng Zhang, Wei Zhong, Jian Liu, Xiuting Huang, Wei He, Hongcheng Zhong, Qingdong Cao   +9 more
wiley   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Imported Systemic Endemic Mycoses in Spain 1997–2021: An Analysis of a National Hospital Database

Mycoses, Volume 68, Issue 1, January 2025.
ABSTRACT Background Systemic endemic mycoses are systemic fungal infections typically found in tropical and subtropical regions. Their global incidence is rising, including in nonendemic countries, mainly due to migration and international travel. They are a major cause of morbidity and mortality worldwide, especially in immunocompromised patients ...
Jara Llenas‐García, Roberto González Beiro, José‐Manuel Ramos‐Rincón, Philip Wikman‐Jorgensen   +3 more
wiley   +1 more source

Unraveling the Genetic Predisposition on Respiratory Infections: From Single Nucleotide Polymorphisms to Inborn Errors of Immunity

Interdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.
Background: The complex interplay between the human genome and microbial pathogens has captured scientific interest, leading to profound insights into the genetic basis of host’s susceptibility to infections. Objective: Here, we explore the spectrum of genetic susceptibility in infectious diseases, ranging from common single nucleotide polymorphisms ...
Francesca Conti, Mattia Moratti, Bianca Laura Cinicola, Riccardo Castagnoli, Riccardo Papa, Silvia Federici, Giuliana Giardino, Lucia Leonardi, Maria Sangerardi, Annarosa Soresina, Gian Luigi Marseglia, Michele Miraglia Del Giudice, Marcello Lanari, Caterina Cancrini, Vassilios Lougaris, Fabio Cardinale, on behalf of the Immunology Committee of the Italian Society of Pediatric Allergology and Immunology (SIAIP), Suraiya Saleem   +17 more
wiley   +1 more source

Perspective on donor‐derived infections in Italy

Transplant Infectious Disease, Volume 26, Issue S1, November 2024.
Abstract Background Expected and unexpected donor‐derived infections (DDI) are a rare event in solid organ transplant (SOT) recipients but are potentially associated with significant morbidity and mortality. To assure the microbial safety of transplantation, both national guidelines and the current, regional, and local epidemiology of infectious ...
Paolo Antonio Grossi, Letizia Lombardini, Raffaele Donadio, Daniela Peritore, Giuseppe Feltrin   +4 more
wiley   +1 more source

ParaDB: A manually curated database containing genomic annotation for the human pathogenic fungi Paracoccidioides spp.

PLoS Neglected Tropical Diseases, 2019
BackgroundThe genus Paracoccidioides consists of thermodymorphic fungi responsible for Paracoccidioidomycosis (PCM), a systemic mycosis that has been registered to affect ~10 million people in Latin America.
David Aciole Barbosa, Fabiano Bezerra Menegidio, Valquíria Campos Alencar, Rafael S Gonçalves, Juliana de Fátima Santos Silva, Renata Ozelami Vilas Boas, Yara Natércia Lima Faustino de Maria, Daniela Leite Jabes, Regina Costa de Oliveira, Luiz R Nunes   +9 more
doaj   +1 more source

Destructive genital and oral ulcers in rural patients

JAAD Case Reports, 2021
Eduardo Mastrangelo Marinho Falcão, MD, MS, Priscila Marques de Macedo, MD, PhD, Dayvison Francis Saraiva Freitas, MD, PhD, Ziadir Francisco Coutinho, MD, PhD, Leonardo Pereira Quintella, MD, PhD, Rodrigo Almeida-Paes, PhD, Rosely Maria Zancopé-Oliveira, PhD, Antonio Carlos Francesconi do Valle, MD PhD   +7 more
doaj   +1 more source

Paracoccidiomicosis en el sistema nervioso central: reporte de un caso

Revista Peruana de Medicina Experimental y Salud Pública
La paracoccidiomicosis es una enfermedad micótica que puede comprometer el sistema nervioso central (SNC). Se presenta el caso de un paciente varón de 45 años, inmunocompetente, de la ciudad de Satipo, que desarrollo paracoccidiomicosis en el SNC sin ...
Jesús Rojas-Jaimes, Raul Castillo Cordova, Delza Tárraga Gonzales   +2 more
doaj  

Biochemical responses in mice experimentally infected with Paracoccidioides brasiliensis and treated with Canova

Brazilian Archives of Biology and Technology, 2006
The objective of this work was to evaluate biochemical parameters in Paracoccidioides brasiliensis infected mice and the effect of Canova medicine on these parameters.
Gisele Takahachi, Márcia Luzia Ferrarezi Maluf, Terezinha Inez Estivalet Svidzinski, Luciene Setsuko Akimoto-Günther, Márcia Rosangela Neves de Oliveira Hübler, Ciomar Aparecida Bersani-Amado, Roberto Kenji Nakamura Cuman   +6 more
doaj   +1 more source