Results 51 to 60 of about 4,243 (161)

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, Volume 292, Issue 13, Page 3430-3448, July 2025.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Transcriptional and proteomic responses to carbon starvation in Paracoccidioides. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: The genus Paracoccidioides comprises human thermal dimorphic fungi, which cause paracoccidioidomycosis (PCM), an important mycosis in Latin America. Adaptation to environmental conditions is key to fungal survival during human host infection.
Patrícia de Sousa Lima, Luciana Casaletti, Alexandre Melo Bailão, Ana Tereza Ribeiro de Vasconcelos, Gabriel da Rocha Fernandes, Célia Maria de Almeida Soares   +5 more
doaj   +1 more source

The Study of Microbial Physiology Under Microoxic Conditions Is Critical but Neglected

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Microbial physiology is mainly studied under aerobic or anaerobic/anoxic conditions, neglecting microbial behaviours in diverse microoxic conditions. The current article revisits the definition of microoxia in light of recent developments in oxygen‐sensing technology and emphasises the need to understand microbial physiology and growth behaviours of ...
Om Prakash, Ashvini Chauhan, Stefan J. Green   +2 more
wiley   +1 more source

The taxonomy of two uncultivated fungal mammalian pathogens is revealed through phylogeny and population genetic analyses

Scientific Reports, 2021
Ever since the uncultivated South American fungal pathogen Lacazia loboi was first described 90 years ago, its etiology and evolutionary traits have been at the center of endless controversies.
Raquel Vilela, Marianne Huebner, Camila Vilela, Gabriella Vilela, Bruno Pettersen, Claudia Oliveira, Leonel Mendoza   +6 more
doaj   +1 more source

Molecular detection and identification of Paracoccidioides brasiliensis [PDF]

Journal of Clinical Microbiology, 1997
Nearly 800 nucleotides from the 5' terminus of the 28S ribosomal gene of Paracoccidioides brasiliensis were sequenced, and a 14-base DNA probe specific for this species was identified. Hybridization results showed that the probe identified P. brasiliensis ribosomal DNA in a panel of ribosomal DNAs representing a total of 48 species of fungi.
G S Sandhu, Bruce C. Kline, R A Aleff, C da Silva Lacaz   +3 more
openaire   +2 more sources

Understanding causes of morbidity and mortality in Southern Hemisphere small Odontoceti: a scoping review

Mammal Review, Volume 55, Issue 2, April 2025.
This review identifies key causes of morbidity and mortality in Southern Hemisphere small Odontoceti, highlighting significant anthropogenic threats and the enhanced need for conservation strategies. Key findings include high rates of entanglements and a diverse range of infectious pathogens. Abstract Marine mammals serve as sentinels for environmental
Rebecca Souter, Anne‐Lise Chaber, Luciana Möller, Lucy Woolford   +3 more
wiley   +1 more source

Establishment of an experimental system to analyse extracellular vesicles during apoplastic fungal pathogenesis

Journal of Extracellular Biology, Volume 4, Issue 2, February 2025.
Abstract Phoma stem canker disease of oilseed rape (Brassica napus) is caused by the extracellular fungal pathogen Leptosphaeria maculans. Although this pathogen resides exclusively in apoplastic spaces surrounding plant cells, the significance of extracellular vesicles (EVs) has not been assessed.
Nathaniel Hearfield, Dominik Brotherton, Zedi Gao, Jameel Inal, Henrik U. Stotz   +4 more
wiley   +1 more source

Assessing the potential risk of human pathogen resistance to medical antifungal treatments arising from agricultural use of fungicides with the same mode of action

Plant Pathology, Volume 74, Issue 2, Page 578-594, February 2025.
A mechanistic basis is described for assessment of resistance risk to medical antifungal treatments from agricultural use of fungicides of the same mode of action. Abstract A mechanistic basis is described for assessment of resistance risk to medical antifungal treatments from agricultural use of fungicides of the same mode of action.
Neil Paveley, Frank van den Bosch, Michael Grimmer   +2 more
wiley   +1 more source

Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Antimicrobial peptides (AMPs) are promising alternatives to conventional treatments for polymicrobial biofilms, which increase pathogen resistance. AMPs disrupt biofilm extracellular matrices and microbial membranes, inhibiting biofilm formation and enhancing antibiotic efficacy. Current research addresses challenges like stability and production costs
Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio   +11 more
wiley   +1 more source

Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients

Brazilian Journal of Infectious Diseases, 2015
Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii.
Marcela Gaviria, Vanessa Rivera, Cesar Muñoz-Cadavid, Luz Elena Cano, Tonny Williams Naranjo   +4 more
doaj   +1 more source