Results 81 to 90 of about 11,266 (199)

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Innate immunity to Paracoccidioides brasiliensis infection [PDF]

Mycopathologia, 2008
Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial pathogen growth and have profound effect on the adaptative immune response that further develops ...
Vera Lúcia Garcia, Calich, Tânia Alves, da Costa, Maíra, Felonato, Celina, Arruda, Simone, Bernardino, Flávio Vieira, Loures, Laura Raquel Rios, Ribeiro, Rita, de Cássia Valente-Ferreira, Adriana, Pina   +8 more
openaire   +2 more sources

Extracellular Vesicles From Fungal Infection in Humans: A Key Player in Immunological Responses

Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.
ABSTRACT Fungal infections cause approximately 1.6 million deaths annually. Diagnosing and treating fungal infections is difficult due to limited access to diagnostic tests and rising antifungal resistance. Extracellular vesicles (EVs) facilitate interactions between fungal cells and hosts, significantly influencing the pathogen‐host relationship ...
Caroline P. de Rezende, Patrick W. S. Santos, Renan A. Piraine, Virgínia C. Silvestrini, Julio C. J. Barbosa, Fabiana C. P. Valera, Edwin Tamashiro, Guilherme G. Podolski‐Gondim, Silvana M. Quintana, Rodrigo Calado, Roberto Martinez, Taicia P. Fill, Márcio L. Rodrigues, Fausto Almeida   +13 more
wiley   +1 more source

Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Differentiation of the Dimorphic Fungal Species Paracoccidioides brasiliensis and Paracoccidioides lutzii [PDF]

, 2015
Isolates of Paracoccidioides brasiliensis and Paracoccidioides lutzii, previously characterized by molecular techniques, were identified for the first time by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS ...
Almeida, Joao Nobrega de, Bagagli, Eduardo, Benard, Gil, De Figueiredo, Dulce S. Y., Del Negro, Gilda M. B., Grenfell, Rafaella C., Juliano, Luiz, Thomaz, Danilo Y., Vidal, Monica S. M.   +8 more
core   +2 more sources

Chlamydospore formation by Paracoccidioides brasiliensis mycelial form [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1989
To investigate the role of some adverse environmental conditions in chlamy-dospore formation by the mycelial form of P. brasiliensis, we cultured four P. brasiliensis isolates (18, Bt4, 1183, Pb9) at 25°C within solid agar medium either rich or poor in nutrients.
Franco, M., Sano, A., Kera, K., Nishimura, K., Takeo, K., Miyaji, M.   +5 more
openaire   +6 more sources

Climate Change, Natural Disasters, and Cutaneous Fungal Infections

International Journal of Dermatology, Volume 64, Issue 8, Page 1349-1355, August 2025.
ABSTRACT Fungal infections are an important source of morbidity and mortality that can manifest as superficial or invasive diseases. Diagnostic techniques for human fungal pathogens remain problematic, and multi‐drug resistance is emerging. This review addresses the potential emergence of new fungal pathogens in changing environments and reported ...
Aditya K. Gupta, Mary Thornbush, Tong Wang   +2 more
wiley   +1 more source

Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients

Brazilian Journal of Infectious Diseases, 2015
Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii.
Marcela Gaviria, Vanessa Rivera, Cesar Muñoz-Cadavid, Luz Elena Cano, Tonny Williams Naranjo   +4 more
doaj   +1 more source

Road-killed wild animals: a preservation problem useful for eco-epidemiological studies of pathogens [PDF]

, 2010
Road-killed wild animals have been for years used for surveillance of vectors of zoonotic pathogens and may offer new opportunities for eco-epidemiological studies.
BAGAGLI, E, BARROZO, L, BOSCO, SMG, RICHINI-PEREIRA, VB, THEODORO, RC   +4 more
core   +2 more sources

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, Volume 292, Issue 13, Page 3430-3448, July 2025.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

The Study of Microbial Physiology Under Microoxic Conditions Is Critical but Neglected

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Microbial physiology is mainly studied under aerobic or anaerobic/anoxic conditions, neglecting microbial behaviours in diverse microoxic conditions. The current article revisits the definition of microoxia in light of recent developments in oxygen‐sensing technology and emphasises the need to understand microbial physiology and growth behaviours of ...
Om Prakash, Ashvini Chauhan, Stefan J. Green   +2 more
wiley   +1 more source