Results 61 to 70 of about 11,427 (259)

Comprometimento pulmonar pelo paracoccidioides brasiliensis

Research, Society and Development, 2023
Paracoccidioidomicose (PCM) é doença granulomatosa sistêmica que pode comprometer qualquer órgão, principalmente pulmões. O presente artigo tem por objetivo realizar uma revisão da literatura sobre o acometimento pulmonar na infecção por P. brasiliensis, abordando aspectos fisiopatológicos, os métodos diagnósticos e a conduta terapêutica mais adequada ...
Caio César Jorge Fonseca, Lucca de Lima Medeiros, Romária Emanuela Carvalho Santos Soares, Ana Cristina Doria dos Santos   +3 more
openaire   +1 more source

Integrated In Silico – In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action

Global Challenges, Volume 9, Issue 12, December 2025.
This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni, Katharina Fuchs, Gianni Galaverna, Peter Macheroux, Luca Dellafiora   +4 more
wiley   +1 more source

Human serum antibody reactivity towards Paracoccidioides brasiliensis antigens treated with sodium metaperiodate Reatividade de anticorpos de soros humanos a antígenos de Paracoccidioides brasiliensis tratados com metaperiodato sódico

Revista da Sociedade Brasileira de Medicina Tropical, 2008
In this study, we evaluated the profile of anti-Paracoccidioides brasiliensis immunoglobulin isotypes in serum from patients with the acute and chronic forms of paracoccidioidomycosis, using the whole Paracoccidioides brasiliensis antigen and the antigen
Ana Paula Ferreira, Thadeu Côrrea, Rosângela Cunha, Marcos José Marques, Maria Angela Montesano, Maria Aparecida Souza, Henrique Couto Teixeira   +6 more
doaj   +1 more source

Molecular Phylogenetic Analysis of Paracoccidioides Species Complex Present in Paracoccidioidomycosis Patient Tissue Samples

Microorganisms, 2023
Paracoccidioidomycosis (PCM) is the main and most prevalent systemic mycosis in Latin America, that until recently, it was believed to be caused only by Paracoccidioides brasiliensis (P. brasiliensis). In 2006, researchers described three cryptic species:
Luciana Bonome Zeminian de Oliveira, Amanda Manoel Della Coletta, Taiane Priscila Gardizani, Hans Garcia Garces, Eduardo Bagagli, Luciana Trilles, Ligia Vizeu Barrozo, Sílvio de Alencar Marques, Julio De Faveri, Luciane Alarcão Dias-Melicio   +9 more
doaj   +1 more source

Detection of the basement membrane-degrading proteolytic activity of Paracoccidioides brasiliensis after SDS-PAGE using agarose overlays containing Abz-MKALTLQ-EDDnp [PDF]

, 1999
We have characterized, in the Paracoccidioides brasiliensis yeast phase, an exocellular SH-dependent serine proteinase activity against Abz-MKRLTL-EDDnp and analogous fluorescent-quenched peptides, and showed that it is also active against constituents ...
Carmona, Adriana Karaoglanovic, Juliano, Luiz, Juliano, Maria Aparecida, Puccia, Rosana, Travassos, Luiz Rodolpho   +4 more
core   +4 more sources

Fungal DNA‐barcoding on a chip: Magnetoresistive biosensors for yeast infection diagnosis

VIEW, Volume 6, Issue 6, December 2025.
The development of a fungal pathogen identification chip is herein demonstrated. Hybridization dynamics were tested against 58 species in silico and 4 species on chip. 95% accuracy, 91% sensitivity, 98% specificity and femtomolar limit of detection were achieved. Future perspectives include the integration of sample pre‐treatment modules.
Maria Zolotareva, Francisco Cascalheira, Rúben Afonso, Maria Corado, Ana Martins, Cátia Caneiras, Cristina Bárbara, Miguel Cacho Teixeira, Diogo Miguel Caetano   +8 more
wiley   +1 more source

Complexo primário da paracoccidioidomicose e hipereosinofilia Primary complex of paracoccidioidomycosis and hypereosinophilia

Jornal Brasileiro de Pneumologia, 2009
A infecção primária por Paracoccidioides brasiliensis é observada raramente. Um paciente masculino de 28 anos de idade apresentou febre, sintomas respiratórios e indisposição durante três meses. Exames radiológicos evidenciaram infiltrado pulmonar apical
Roberto Martinez, Maria Janete Moya
doaj   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

REACTIVITY OF ANTI-GP43 ANTIBODIES FROM PARACOCCIDIOIDES BRASILIENSIS ANTISERUM WITH EXTRACTS FROM CUTANEOUS LESIONS OF LOBO'S DISEASE: PRELIMINARY NOTE

Revista do Instituto de Medicina Tropical de São Paulo, 1997
We demonstrated through several immunochemical tests the presence of GP-43 from P. brasiliensis in extracts of cutaneous lesions from Jorge Lobo's disease.
Mônica Scarpelli Martinelli VIDAL, Selma Aliotti PALACIOS, Natalina TAKAHASHI DE MELO, Carlos da Silva LACAZ   +3 more
doaj   +1 more source

Serology of paracoccidioidomycosis [PDF]

, 2008
This review provides the background for understanding the role of a battery of diagnostic methods in paracoccidioidomycosis (PCM). This systemic mycosis is a disease endemic in many regions of Latin America, with sporadic cases also occurring throughout ...
Camargo, Zoilo Pires de
core   +1 more source