Results 81 to 90 of about 6,403 (197)

Immune Phenotypes in Patients With Invasive Mould Infection Support the Use of PD‐1 Inhibition as Potential Treatment Option

Mycoses, Volume 68, Issue 3, March 2025.
ABSTRACT Background Invasive mould infections (IMI) cause substantial morbidity and mortality in populations at risk. Novel treatment approaches are urgently needed. Targeting immune checkpoints may reverse hyporesponsiveness of the innate and adaptive immune systems.
Sibylle C. Mellinghoff, Martin Thelen, Michael von Bergwelt‐Baildon, Hans A. Schlößer, Oliver A. Cornely, Rosanne Sprute, Jannik Stemler, Leonie Mayer, Leonie Marie Weskamm, Monika Friedrich, My Linh Ly, Christine Dahlke, Marylyn M. Addo   +12 more
wiley   +1 more source

Thoracic intraspinal paracoccidioidomycosis: case report Paracoccidioidomicose intramedular torácica: relato de caso

Arquivos de Neuro-Psiquiatria, 1996
Intramedullary lesions caused by Paracoccidioides brasiliensis have been rarely described. Its diagnosis may be challenging and surgical approach is indicated for diagnostic and therapeutic purposes. We hereby report a case with MRI and surgical findings
Robertson A. B. Pacheco, Walter O. Arruda, Sonival C. Hunhevicz, Mário H. Tsubouchi, Luiz F. Bleggi Torres   +4 more
doaj   +1 more source

IL‐6 Degradation by Secreted Proteases From Paracoccidioides restrepiensis

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Paracoccidioidomycosis is a systemic fungal disease caused by Paracoccidioides spp., predominantly affecting populations in Latin America, with Brazil reporting the highest number of cases. The infection is associated with severe pulmonary and systemic manifestations. Previous studies have highlighted the role of fungal proteases in adhesion, invasion,
Priscila de Oliveira, Bianca Carla Silva Campitelli Barros, Maria Aparecida Juliano, Aparecida Sadae Tanaka, Adriana Karaoglanovic Carmona, Saara Maria Batista dos Santos, Paloma Korehisa Maza, Rosana Puccia, Alexandre Keiji Tashima, Erika Suzuki, Nagarajan Raju   +10 more
wiley   +1 more source

Infection and pulmonary vascular diseases consortium: United against a global health challenge

Pulmonary Circulation, Volume 14, Issue 4, October 2024.
Abstract Leveraging the potential of virtual platforms in the post‐COVID‐19 era, the Infection and Pulmonary Vascular Diseases Consortium (iPVDc), with the support of the Pulmonary Vascular Research Institute (PVRI), launched a globally accessible educational program to highlight top‐notch research on inflammation and infectious diseases affecting the ...
S. D. Oliveira, S. Almodóvar, G. Butrous, V De Jesus Perez, A. Fabro, B. B. Graham, A. Mocumbi, P. S. Nyasulu, O. Tura‐Ceide, R. K. F. Oliveira, N. K. Dhillon, Infection and Pulmonary Vascular Diseases Consortium   +11 more
wiley   +1 more source

Disseminated paracoccidioidomycosis diagnosis based on oral lesions

Contemporary Clinical Dentistry, 2014
Paracoccidioidomycosis (PCM) is a deep mycosis with primary lung manifestations that may present cutaneous and oral lesions. Oral lesions mimic other infectious diseases or even squamous cell carcinoma, clinically and microscopically.
Liana Preto Webber, Manoela Domingues Martins, Marcia Gaiger de Oliveira, Etiene Andrade Munhoz, Vinicius Coelho Carrard   +4 more
doaj   +1 more source

Exome Sequencing of a Blastomycosis Case–Control Cohort From Manitoba and Northwestern Ontario, Canada

Mycoses, Volume 67, Issue 9, September 2024.
ABSTRACT Background Blastomycosis is a pulmonary disease caused by Blastomyces spp., a group of pathogenic dimorphic fungi endemic to a number of geographic regions, specifically Manitoba and northwestern Ontario, Canada. Immunosuppression is a major risk factor affecting disease susceptibility, yet host immunity is not well understood.
Paul Jankowski, Emma R. Lee, John Embil, Yoav Keynan, Paul J. McLaren   +4 more
wiley   +1 more source

Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis

Frontiers in Immunology, 2017
Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
F. Tristão, F. A. Rocha, D. Carlos, Natália Ketelut-Carneiro, C. O. Souza, Cristiane Milanezi, J. Silva   +6 more
semanticscholar   +1 more source

From Mendel to mycoses: Immuno‐genomic warfare at the human–fungus interface

Immunological Reviews, Volume 322, Issue 1, Page 28-52, March 2024.
Summary Fungi are opportunists: They particularly require a defect of immunity to cause severe or disseminated disease. While often secondary to an apparent iatrogenic cause, fungal diseases do occur in the absence of one, albeit infrequently. These rare cases may be due to an underlying genetic immunodeficiency that can present variably in age of ...
Donald C. Vinh
wiley   +1 more source

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis

Frontiers in Immunology, 2017
The NOD-like receptor P3 (NLRP3) inflammasome is an intracellular multimeric complex that triggers the activation of inflammatory caspases and the maturation of IL-1β and IL-18, important cytokines for the innate immune response against pathogens.
C. Feriotti, E. F. de Araújo, F. V. Loures, T. A. da Costa, N. A. L. Galdino, D. Zamboni, V. Calich   +6 more
semanticscholar   +1 more source

Functional neutrophil disorders: Chronic granulomatous disease and beyond

Immunological Reviews, Volume 322, Issue 1, Page 71-80, March 2024.
Summary Since their description by Metchnikoff in 1905, phagocytes have been increasingly recognized to be the entities that traffic to sites of infection and inflammation, engulf and kill infecting organisms, and clear out apoptotic debris all the while making antigens available and accessible to the lymphoid organs for future use.
Christa S. Zerbe, Steven M. Holland
wiley   +1 more source