Results 41 to 50 of about 1,653,511 (308)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
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A review on the extreme rainfall studies in India
Natural Hazards ResearchClimate vulnerability in the Indian region becomes a major concern due to the frequent hydro-meteorological extreme events throughout the year. The number of extreme rainfall events (ERE) associated with monsoon, thunderstorms and short-spanned local ...
Payoshni Samantray +1 more
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SOCIAL APPROACH OF THE RELATIONSHIP CONCEPT IN INTERNATIONAL RELATIONS
Studia Universitatis Babeş-Bolyai. Studia Europaea, 2017 In this paper, we will address to deficits of the study of relationship construction in IR by approaching the meaning of the concept in network structures.
Salanțiu TUDOR
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Meteorological Applications, 2020 A total of 32 rainfall events spanning the period from 2012 to 2014 over the urban Indian city of Bangalore were simulated using the Weather Research and Forecast (WRF) model.
P. Ajilesh +3 more
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At-turas: Jurnal Studi Keislaman, 2023 This research is based on the gap between the theory of religious conflict and the reality of the religious transition paradigm currently. Media issues have warmed up again lately with some news about the policy of disbanding radical mass organizations ...
Rif'an Humaidi +2 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
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A new paradigm for classifying and treating HER2‐positive breast cancer
Cancer Reports, 2023 Background Because of the phenomenal success of treatment with monoclonal antibodies and antibody‐drug conjugates targeting human epidermal growth factor receptor 2 (HER2), most patients with early‐stage HER2‐positive breast cancer (HER2+ BC) and some ...
Xuexin He +2 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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