Results 41 to 50 of about 1,147,116 (292)
Quasicrystals – A Paradigm Shift in Crystallography?
CHIMIA, 2014 The discovery of quasicrystals had important consequences for our understanding of long-range order in thermodynamic equilibrium, the definition of the term 'crystal' as well as diffraction theory.
Walter Steurer
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The Canadian ‘Model Forest’ approach : a way forward for Tasmania? [PDF]
, 2004 Forest policy and forestry management in Tasmania have undergone a number of changes in the last thirty years, many explicitly aimed at improving industry sustainability, job security, and forest biodiversity conservation.
Gray, Matthew, Wolfenden, John A.J.
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
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Shifting Sugars and Shifting Paradigms
PLOS Biology, 2015 No organism lives in a constant environment. Based on classical studies in molecular biology, many have viewed microbes as following strict rules for shifting their metabolic activities when prevailing conditions change. For example, students learn that the bacterium Escherichia coli makes proteins for digesting lactose only when lactose is available ...
openaire +4 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
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Idiopathic recurrent pericarditis — a paradigm shift?
Российский кардиологический журнал, 2019 Idiopathic recurrent pericarditis (IRP) is a relatively rare inflammatory disease of the pericardium, often requiring emergency medical care, associated with a high percentage of temporary disability and significant economic costs.
V. Yu. Myachikova +3 more
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Mobile open social language learning: towards a paradigm shift [PDF]
, 2018 The authors have undertaken a combination of theoretical analysis together with reflection on a range of practical applications and explorations of mobile, social and open learning, over the years, leading them to the conclusion that a new language ...
Barcena, Elena +3 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
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Reversible Gates: A Paradigm Shift in Computing
IEEE Open Journal of Circuits and Systems, 2023 The reversible gate has been one of the emerging research areas that ensure a continual process of innovation trends that explore and utilizes the resources.
Syed Farah Naz, Ambika Prasad Shah
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
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