Results 31 to 40 of about 39,652 (286)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Resum executiu. La gestió del talent. [PDF]
, 2008 Resum executiu del director de la revista ...
Llarch, Enric
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Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
La representació occidental de la Xina moderna: orientalisme, culturalisme i crítica historiogràfica
Digithum, 2008 La percepció que des d'Occident s'ha tingut de la Xina com a ens històric ha evolucionat al llarg dels segles. La Xina va passar de ser un país de prodigis i meravelles en el món medieval i una cultura refinada i erudita al començament de la modernitat ...
David Martínez-Robles
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Revue Francophone de Recherche en Ergothérapie, 2022 À partir du cas de figure de l’application d’un algorithme clinique en ergothérapie (Algo) dans le réseau de la santé et des services sociaux du Québec, ce texte vulgarise les paradigmes et les concepts subjacents au processus d’application des ...
Mélanie Ruest, Manon Guay
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Agroécologie et sécurité alimentaire : pour un mariage forcé [PDF]
, 2019 Les luttes autour de la nécessité de transformer les paradigmes technologiques de l'agriculture pour faire face aux urgences écologiques et sociales mondiales (extinction de la biodiversité, changement climatique, accroissement des inégalités), semblent ...
Sourisseau, Jean-Michel, Temple, Ludovic
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Introduction. Les paradigmes de la justice [PDF]
Meta: Research in Hermeneutics, Phenomenology and Practical Philosophy, 2009 Theories of justice are marred by a permanent state of conflict because they express prejudices whose source lies in the lifeworld. One may regard these theories as interpretations of the concept of justice. Assuming a strong meaning of “theory,” one can
Cornelui Bîlbă
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