E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
IMPACT OF TRADE OPENNESS AND MACROECONOMIC VARIABLES ON GDP GROWTH OF PAKISTAN [PDF]
Paradigms, 2013 This study is about the impact of trade openness and selected macroeconomic variables on economic growth of Pakistan. Economic growth of Pakistan is measured interms of annual nominal GDP growth rate.
Muhammad Ramzan +2 more
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
P168: Nutritional markers of histamine intolerance in Ehlers-Danlos syndromes
Genetics in Medicine Open, 2023 Jessica Pizano +5 more
doaj +1 more source
Does Comparative Advantage Affect Economic Growth: A Case of Pakistan with Asian, OECD and Latin American Economies 1982-2011 [PDF]
Paradigms, 2015 Present study endeavours to assess the comparative advantage of Pakistan’s exports to selected regional economies around the world namely Asian, OECD, and Latin American economies.
Ijaz Hussain Bokhari +2 more
doaj
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Transformational Leadership Style and Organization Commitment [PDF]
Paradigms, 2015 This research is about transformational leadership style on organization commitment in Punjab. We collected data through questionnaire from education and banking sector of Punjab.
Muhammad Ramzan Mehar, , and +3 more
doaj
Research in Integrated Care: The Need for More Emergent, People-Centred Approaches
International Journal of Integrated Care, 2020 The International Foundation for Integrated Care (IFIC) recently celebrated its 20th International Conference (ICIC20) through a virtual event that brought together patients and carers, academics, care professionals, NGOs, policy-makers and industry ...
Wilma van der Vlegel-Brouwer +4 more
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Investigation Of Export-Led Growth And Growth-Led Export Hypotheses: A Study On Pakistan Exports To USA, UAE and UK [PDF]
Paradigms, 2011 his article is about investigation of export-led growth and growth-led export hypotheses in case of Pakistan exports to top three exports partners namely: USA, UAE and UK. Time series data over the period of 1975 to 2012 has been used.
Muhammad Azhar Ikram Ahmad +2 more
doaj