Results 51 to 60 of about 956,237 (293)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Performance Philosophy, 2017 Nietzsche’s Dionysus, admittedly, represents a direct provocation and an attack on the classical interpretation accepted since Winckelmann, an interpretation that elevates the Apollonian to its central point of focus; Nietzsche’s introduction of another ...
Dieter Mersch
doaj +1 more source
Quantitative Finance and Economics, 2021 Due to the problem of "true value agnostic" in the measurement of the real world, people believe that the existing methods can be closer to the true value by improving them.
Dong Qiu , Dongju Li
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Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
To Overcome Ethical Dilemmas in an Organization: Paradox and Ethics of Freedom Can Help [PDF]
Business Ethics and LeadershipA theoretical model for managers responding to a morally challenging situation is developed in the article. This model explores and examines how managers deal with paradoxes created by ethical dilemmas.
Benoît Cherré, Nathalie Lemieux
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The Generalised Liar Paradox: A Quantum Model and Interpretation
, 2004 The formalism of abstracted quantum mechanics is applied in a model of the generalized Liar Paradox. Here, the Liar Paradox, a consistently testable configuration of logical truth properties, is considered a dynamic conceptual entity in the cognitive ...
Bart D’Hooghe +8 more
core +1 more source
Journal of the American College of Cardiology, 2014 Paradoxical embolism is an important clinical entity among patients with venous thromboembolism in the presence of intracardiac or pulmonary shunts. The clinical presentation is diverse and potentially life-threatening. Although the serious nature and complications of paradoxical embolism are recognized, the disease entity is still rarely considered ...
Windecker, Stephan +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Pervasive Technologies and the Paradoxes of Multimodal Digital Communication
Lea, 2014 Contemporary societies are greatly challenged by paradoxes in all facets of life. Digital communication encodes and produces meaning by making use of these contradictory relations. In this contribution, three digital paradoxes will be presented.
Sandra Petroni
doaj +1 more source