Results 61 to 70 of about 956,237 (293)
Frontiers in Cardiovascular Medicine, 2022 BackgroundApolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) were identified targets for blood lipid management among coronary artery disease (CAD) patients.
Huanqiang Li +48 more
doaj +1 more source
Why Black Hole Information Loss is Paradoxical [PDF]
, 2017 I distinguish between two versions of the black hole information-loss paradox. The first arises from apparent failure of unitarity on the spacetime of a completely evaporating black hole, which appears to be non-globally-hyperbolic; this is the most ...
Wallace, David
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Outlaw Lovers and Aporetic Politics: Derrida’s The Politics of Friendship and Sherman Alexie’s ‘South by Southwest’ [PDF]
Limina: A Journal of Historical and Cultural Studies, 2014 This article provides a comparative reading of Jacques Derrida’s The Politics of Friendship with Sherman Alexie’s short story ‘South by Southwest’. In these texts, ‘friendship’ or love is impossible to achieve by seeking conformance to pre-existing ...
Mara Steele
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Sparks of reality: on the temporalities of the photographic image
Aisthesis, 2018 Within the context of the contemporary heterogeneity of photographic practices, the present text describes some of the possibilities of understanding the temporality of photographs, giving an account of some important theoretical references (Benjamin ...
Nélio Conceição
doaj
A Dichotomic Analysis of the Surprise Examination Paradox [PDF]
, 2002 This paper presents a dichotomic analysis of the surprise examination paradox. In section 1, I analyse the surprise notion in detail. I introduce then in section 2, the distinction between a monist and dichotomic analysis of the paradox.
Franceschi, Paul
core +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source