Results 31 to 40 of about 8,962 (265)
Are Zeno’s Arguments Unsound Paradoxes?
Peitho, 2013 Zeno’s arguments are generally regarded as ingenious but downright unsound paradoxes, worth of attention mainly to disclose why they go wrong or, alternatively, to recognise them as clever, even if crude, anticipations of modern views on the space, the ...
Guido Calenda
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Journal of Modern Science, 2021 Objectives The aims of the article focus on an evolutionary and retrospective look at the reality of contemporary public management in Poland in the second decade of the 21st century and considering the reality of public management in the convention of ...
Bogdan Nogalski +2 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Unveiling paradoxes: navigating SMEs readiness in the post-pandemic normality
Cogent Business & ManagementThis paper centers on the challenges posed by the pandemic crisis, examining the crucial organizational and strategic alignments, as well as the inherent paradoxes that are pivotal in nurturing competitiveness within the changed post-pandemic business ...
Rafael Castro, António Carrizo Moreira
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Paradoxes of Nurse Training in the Context of the 70th Anniversary of Reanimatology
Общая реаниматология, 2006 Objective: To assess the professional education of nurses in the context of development of Russian reanimatology.Materials and methods. The official curriculums of nurse training over 70 years of Russian reanimatology were comparatively analyzed.Results.
A. I. Levshankov
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The logical challenge of negative theology
Studies in Logic, Grammar and Rhetoric, 2018 In this paper I present four interpretations of so-called negative theology and provide a number of attempts to model this theory within a formal system. Unfortunately, all of them fail in some manner.
Urbańczyk Piotr
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Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory
Biomolecules, 2022 The currently accepted theory on the influence of DNA mutations on carcinogenesis (the Somatic Mutation Theory, SMT) is facing an increasing number of controversial results that undermine the explanatory power of mutated genes considered as “causative ...
Noemi Monti +5 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source