Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
New parallel computing algorithm of molecular dynamics for extremely huge scale biological systems. [PDF]
J Comput Chem, 2021 Jung J +11 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
LDkit: a parallel computing toolkit for linkage disequilibrium analysis. [PDF]
BMC Bioinformatics, 2020 Tang Y +6 more
europepmc +1 more source
Parallel Computing on the Preheating and Commissioning of Hot Oil Pipelines [PDF]
, 2013 Yutian Li, Changchun Wu, Yang Yu
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A Parallel Evolutionary Computing-Embodied Artificial Neural Network Applied to Non-Intrusive Load Monitoring for Demand-Side Management in a Smart Home: Towards Deep Learning [PDF]
, 2020 Yu‐Hsiu Lin
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FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
JOINT for large-scale single-cell RNA-sequencing analysis via soft-clustering and parallel computing. [PDF]
BMC Genomics, 2021 Cui T, Wang T.
europepmc +1 more source
IBM Bergen Scientific Centre and the International Conference On Vector and Parallel Computing [PDF]
, 1988 P. W. Gaffney
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Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source