Results 71 to 80 of about 4,199,345 (361)
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
PFASUM: a substitution matrix from Pfam structural alignments
BMC Bioinformatics, 2017 Background Detecting homologous protein sequences and computing multiple sequence alignments (MSA) are fundamental tasks in molecular bioinformatics. These tasks usually require a substitution matrix for modeling evolutionary substitution events derived ...
Frank Keul +3 more
doaj +1 more source
PkMin: Peak Power Minimization for Multi-Threaded Many-Core Applications
Journal of Low Power Electronics and Applications, 2020 Multiple multi-threaded tasks constitute a modern many-core application. An accompanying generic Directed Acyclic Graph (DAG) represents the execution precedence relationship between the tasks.
Arka Maity, Anuj Pathania, Tulika Mitra
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Transductive Nonnegative Matrix Tri-Factorization
IEEE Access, 2020 Nonnegative matrix factorization (NMF) decomposes a nonnegative matrix into the product of two lower-rank nonnegative matrices. Since NMF learns parts-based representation, it has been widely used as a feature learning component in many fields.
Xiao Teng +4 more
doaj +1 more source
Railway Air Brake Model and Parallel Computing Scheme
, 2017 This paper developed a detailed fluid dynamics model and a parallel computing scheme for air brake systems on long freight trains. The model consists of subsystem models for pipes, locomotive brake valves, and wagon brake valves.
Qing Wu +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Parallel Computation of Echelon Forms [PDF]
, 2014 We propose efficient parallel algorithms and implementations on shared memory architectures of LU factorization over a finite field. Compared to the corresponding numerical routines, we have identified three main difficulties specific to linear algebra over finite fields.
Dumas, Jean-Guillaume +3 more
openaire +4 more sources
Parallel Computing for Brain Simulation [PDF]
Current Topics in Medicinal Chemistry, 2017 The human brain is the most complex system in the known universe, it is therefore one of the greatest mysteries. It provides human beings with extraordinary abilities. However, until now it has not been understood yet how and why most of these abilities are produced.For decades, researchers have been trying to make computers reproduce these abilities ...
Pastur-Romay, L.A. +3 more
openaire +3 more sources