Results 71 to 80 of about 1,134,922 (335)

Multibody Dynamics Model of a Human Hand for Haptics Interaction [PDF]

, 2008
In this paper we propose a strategy for modelling a human hand for Haptics interaction. The strategy consists in a parallel computing architecture that calculates the dynamics of a hand; this is accomplished by computing the dynamics of each finger in a ...
Aracil Santonja, Rafael, Carrera Calderon, Isela Guadalupe, Ferre Pérez, Manuel, Moreno Avalos, Hector, Saltaren Pazmiño, Roque Jacinto, Yime, Eugenio   +5 more
core   +1 more source

Simple parallel and distributed algorithms for spectral graph sparsification

, 2014
We describe a simple algorithm for spectral graph sparsification, based on iterative computations of weighted spanners and uniform sampling. Leveraging the algorithms of Baswana and Sen for computing spanners, we obtain the first distributed spectral ...
Jonathan, Koutis Ioannis, Koutis Ioannis, Livne Oren E., Peng Richard   +4 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Temperature-Dependent Hydrogen Modulations of Ultra-Scaled a-IGZO Thin Film Transistor Under Gate Bias Stress

IEEE Open Journal of Nanotechnology
Recently, a-IGZO has advanced toward the next-generation electronics system because of its compatibility with complementary metal oxide semiconductor (CMOS) and back-end-of-line (BOEL) based systems. A systematic electrical characterization of a-IGZO TFT
Muhammad Aslam, Shu-Wei Chang, Min-Hui Chuang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li   +5 more
doaj   +1 more source

GPU cards as a low cost solution for efficient and fast classification of high dimensional gene expression datasets [PDF]

, 2010
The days when bioinformatics tools will be so reliable to become a standard aid in routine clinical diagnostics are getting very close. However, it is important to remember that the more complex and advanced bioinformatics tools become, the more ...
Benso, Alfredo, Di Carlo, Stefano, Politano, Gianfranco Michele Maria, Savino, Alessandro, Scionti, A.   +4 more
core  

HSTREAM: A directive-based language extension for heterogeneous stream computing

, 2018
Big data streaming applications require utilization of heterogeneous parallel computing systems, which may comprise multiple multi-core CPUs and many-core accelerating devices such as NVIDIA GPUs and Intel Xeon Phis.
Memeti, Suejb, Pllana, Sabri
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Electrical Characteristics of ML and BL MoS₂ GAA NS FETs With Source/Drain Metal Contacts

IEEE Journal of the Electron Devices Society
This paper reports source/drain (S/D) contact issues in monolayer and bilayer (BL) $\mathrm {MoS_{2}}$ devices through density-functional-theory (DFT) calculation and device simulation.
Yueh-Ju Chan, Min-Hui Chuang, Yiming Li
doaj   +1 more source