Results 51 to 60 of about 4,060,865 (318)

Barriers and facilitators of cross-sectoral data linkage to inform healthy public policy and practice: lessons from three case study projects in Scotland.

International Journal of Population Data Science, 2022
Objectives We sought to describe barriers and facilitators faced by three research projects aiming to link routinely-collected data across various sectors, to produce evidence to inform healthy public policy.
Kristina Cimova, David Henderson, Mirjam Allik, Denise Brown, Petra Meier, Charlie Mayor, Nick Watson, Peter Craig, Emily Tweed   +8 more
doaj   +1 more source

Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms [PDF]

, 2009
A genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affected and 1602 unaffected genotyped individuals ...
D Walsh, Gejman, P. V., D F Levinson, Alexander, M., Ribble, R, Mallet, J., Wormley, B., Godard, S, O'Neill, A., Dikeos, D., Alexander, M, Owen, Michael John, F B Lerer, Holmans, PA, Wormley, B, O'Donovan, MC, Liang, KY, R R Crowe, Norton, N., Jay, M., Nertney, D., Silverman, J. M., Levinson, D. F., Mowry, Bryan, Sanders, A. R., Nestadt, G., P A Holmans, Walsh, D., Pulver, A. E., V K Lasseter, Laurent, C, Kendler, K. S., A O'Neill, A E Pulver, C Laurent, Holmans, Peter Alan, G Nestadt, M J Owen, M Alexander, Holmans, P. A., O'Donovan, Michael Conlon, D B Wildenauer, Albus, M., O'Neill, Anthony, Norton, N, P V Gejman, Gejman, PV, Wildenauer, DB, M Albus, Maier, W, Williams, N. M., Nestadt, G, Schwab, SG, G Papadimitriou, Nertney, D, Papadimitriou, G, Lasseter, V. K., D Nertney, Liang, K. Y., Lerer, F. B., Lasseter, VK, O'Donovan, M. C., Duan, J., K S Kendler, Mallet, J, O'Neill, A, N M Williams, J Duan, Mowry, B. J., Duan, J, B Riley, D Dikeos, Owen, M. J., M C O'Donovan, B J Mowry, J Mallet, Owen, MJ, Laurent, C., Norton, Nadine, Jay, M, Crowe, R. R., B Wormley, Maier, W., Albus, M, Walsh, D, R Ribble, Schwab, S. G., S G Schwab, S Godard, N Norton, W Maier, Papadimitriou, G., M Jay, Riley, B, Williams, Nigel Melville, Kendler, KS, Williams, NM, A R Sanders, Lerer, FB, Riley, B., K Y Liang, Pulver, AE, Sanders, AR, Godard, S., Ribble, R., Wildenauer, D. B., J M Silverman   +106 more
core   +2 more sources

604 Development of Biped Running Robot with Parallel Linkage

The Proceedings of Ibaraki District Conference, 2014
Ryou Kondo
exaly   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation. [PDF]

FEBS Open Bio
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Tomkova M, Mirossay A, Sedlak E.
europepmc   +2 more sources

BatchMap: A parallel implementation of the OneMap R package for fast computation of F1 linkage maps in outcrossing species

PLoS ONE, 2017
With the rapid advancement of high throughput sequencing, large numbers of genetic markers can be readily and cheaply acquired, but most current software packages for genetic map construction cannot handle such dense input.
Bastian Schiffthaler, C. Bernhardsson, P. Ingvarsson, N. Street   +3 more
semanticscholar   +1 more source

Multi-Objective Intelligent Decision and Linkage Control Algorithm for Mine Ventilation

Energies, 2022
A novel bare-bones particle swarm optimization (BBPSO) algorithm is proposed to realize intelligent mine ventilation decision-making and overcome the problems of low precision, low speed, and difficulty in converging on an optimal global solution.
Junqiao Li, Yucheng Li, W. Zhang, Jinyang Dong, Y. Cui   +4 more
semanticscholar   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

NC-Link: A New Linkage Method for Efficient Hierarchical Clustering of Large-Scale Data

IEEE Access, 2017
In various disciplines, hierarchical clustering (HC) has been an effective tool for data analysis due to its ability to summarize hierarchical structures of data in an intuitive and interpretable manner.
Yongkweon Jeon, Jaeyoon Yoo, Jongsun Lee, Sungroh Yoon   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source