Results 31 to 40 of about 5,804 (269)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Kinematic Analysis of a 3-Axis Parallel Manipulator: The P3
Advances in Mechanical Engineering, 2013 This paper presents kinematic analysis of a 3-axis parallel manipulator, called P3. The P3 parallel manipulator is developed based on a 3-PRRU parallel mechanism, where P denotes prismatic pair, R revolute pair, and U universal joint.
Qiaohong Chen +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Kinematics and Workspace Analysis and Numerical Simulation of the 3-PRRRR Parallel Manipulator
Jixie chuandong, 2017 The Working space is an important performance and design index in evaluating parallel manipulator.The 3-PRRRR parallel manipulator branched chain is simplified reasonably,by using the D-H method,the 3-PRRRR parallel manipulator inverse kinematic analysis
Shi Mengrui, Zhaoxinhua
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Modal Decoupled Dynamics-Velocity Feed-Forward Motion Control of Multi-DOF Robotic Spine Brace
IEEE Access, 2018 Based on the parallel robotic manipulator, this paper proposes a motion control strategy for the novel robotic spine brace for spinal rehabilitation exercises.
Xinjian Niu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Design and Analysis of an Annular 3-PPR Planar Parallel Mechanism
Jixie chuandong, 2023 In order to enlarge the rotation workspace of the manipulator, an annular 3-PPR planar parallel mechanism with full rotation capability is proposed. Resorting to homogeneous transformation and closed vector method, the inverse kinematics solution of the ...
Wu Xiaoyong, Li Yiyi, Zhang Kaifei
doaj