Results 41 to 50 of about 5,804 (269)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Kinematic and Dynamic Analysis of the Partially Decoupled Parallel Manipulator
Jixie chuandong, 2022 Aiming at the machining of complex curved surface parts with parallel machine tools， a novel partially decoupled parallel manipulator （PM） is proposed. The degree of freedom and the decoupling performance of the mechanism are analyzed.
Canguo Zhang +3 more
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Kinematic and Elastostatic Design Optimisation of the 3-DOF Gantry-Tau Parallel Kinematic Manipulator [PDF]
Modeling, Identification and Control, 2009 One of the main advantages of the Gantry-Tau machine is a large accessible workspace/footprint ratio compared to many other parallel machines. The Gantry-Tau improves this ration further by allowing a change of assembly mode without internal link ...
Ilya Tyapin, Geir Hovland
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Analysis and Design for 3-RPRR Similarly Planar Fully Compliant Parallel Manipulator
Jixie chuandong, 2015 A fully compliant parallel manipulator can achieve multi-dimensional motions,but it has obvious limitations in the micro-position fields for the structure and size.A new mechanism which is called 3-RPRR similarly planar fully compliant parallel ...
Zhu Dachang, Li Yan, Zhang Tao
doaj
Mechanism Design and Simulation Analysis of Hybrid Serial-Parallel Underwater Dredging Manipulator
水下无人系统学报In recent years, underwater robots have emerged as a novel solution for the removal of sediments at the bottom of reservoirs, with underwater manipulators being the primary tool for dredging operations.
Yin XIA +4 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Orientational Capability Analysis of a 2UPR-SPR Parallel Manipulator
Jixie chuandong, 2019 The parallel module of Exechon machine tool is developed based on the 3 degree-of-freedom (DOF) 2UPR-SPR mechanism, which is a parallel spindle head with two rotational (orientational) DOFs and one translational DOF.
Che Linxian +3 more
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