Results 41 to 50 of about 50,107 (254)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Kinematically Redundant Octahedral Motion Platform for Virtual Reality Simulations

, 2017
We propose a novel design of a parallel manipulator of Stewart Gough type for virtual reality application of single individuals; i.e. an omni-directional treadmill is mounted on the motion platform in order to improve VR immersion by giving feedback to ...
B Dasgupta, DM Downing, FM Hamdoon, J Kotlarski, J Lee, J Wang, J-P Merlet, J-P Merlet, KH Hunt, LT Schreiber, P Bande, Y Cao   +11 more
core   +1 more source

Pose, posture, formation and contortion in kinematic systems [PDF]

, 2002
The concepts of pose, posture, formation and contortion are defined for serial, parallel and hybrid kinematic systems. Workspace and jointspace structure is examined in terms of these concepts.
CM Gosselin, J Duffy, J Rooney, J Rooney, J-P Merlet, KH Hunt, KH Hunt, M Husty, M Raghavan, TK Taney   +9 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Kinematic Analysis of a 3-Axis Parallel Manipulator: The P3

Advances in Mechanical Engineering, 2013
This paper presents kinematic analysis of a 3-axis parallel manipulator, called P3. The P3 parallel manipulator is developed based on a 3-PRRU parallel mechanism, where P denotes prismatic pair, R revolute pair, and U universal joint.
Qiaohong Chen, Zhi Chen, Xinxue Chai, Qinchuan Li   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Kinematics and Workspace Analysis and Numerical Simulation of the 3-PRRRR Parallel Manipulator

Jixie chuandong, 2017
The Working space is an important performance and design index in evaluating parallel manipulator.The 3-PRRRR parallel manipulator branched chain is simplified reasonably,by using the D-H method,the 3-PRRRR parallel manipulator inverse kinematic analysis
Shi Mengrui, Zhaoxinhua
doaj  

Methods for autonomous wristband placement with a search-and-rescue aerial manipulator [PDF]

, 2018
A new robotic system for Search And Rescue (SAR) operations based on the automatic wristband placement on the victims’ arm, which may provide identification, beaconing and remote sensor readings for continuous health monitoring. This paper focuses on the
Fernández-García, Emilio, Gandarias, Juan Manuel, Garcia-Cerezo, Alfonso J., García-Núñez, Francisco, Gómez-de-Gabriel, Jesús Manuel, Pérez-Maldonado, Francisco   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source