Results 71 to 80 of about 2,520,496 (344)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Algorithm for Computing Cusp Points in the Joint Space of 3-RPR Parallel Manipulators [PDF]

, 2006
This paper presents an algorithm for detecting and computing the cusp points in the joint space of 3-RPR planar parallel manipulators. In manipulator kinematics, cusp points are special points, which appear on the singular curves of the manipulators. The
Chablat, Damien, Wenger, Philippe, Zein, Mazen   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Computation of parallel link manipulator dynamics

Proceedings of IECON '93 - 19th Annual Conference of IEEE Industrial Electronics, 1994
This paper proposes an algorithm, for calculating the inverse dynamics of link manipulators. First, we derive a method to calculate the inverse dynamics of a general type of parallel link mechanism using the method proposed by Luh and Zeng., which is developed for a simple closed link mechanism and yields the inverse dynamics of the simple closed link ...
Kazuhiro Kosuge, Kouji Takeo, Toshio Fukuda, Katsumi Kai, Tomo Mizuno, Hiroaki Tomimatsu   +5 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis and Design for 3-RPRR Similarly Planar Fully Compliant Parallel Manipulator

Jixie chuandong, 2015
A fully compliant parallel manipulator can achieve multi-dimensional motions,but it has obvious limitations in the micro-position fields for the structure and size.A new mechanism which is called 3-RPRR similarly planar fully compliant parallel ...
Zhu Dachang, Li Yan, Zhang Tao
doaj  

Mechanism Design and Simulation Analysis of Hybrid Serial-Parallel Underwater Dredging Manipulator

水下无人系统学报
In recent years, underwater robots have emerged as a novel solution for the removal of sediments at the bottom of reservoirs, with underwater manipulators being the primary tool for dredging operations.
Yin XIA, Wenbin SU, Qiao HU, Jian ZHANG, Lin SHI   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Orientational Capability Analysis of a 2UPR-SPR Parallel Manipulator

Jixie chuandong, 2019
The parallel module of Exechon machine tool is developed based on the 3 degree-of-freedom (DOF) 2UPR-SPR mechanism, which is a parallel spindle head with two rotational (orientational) DOFs and one translational DOF.
Che Linxian, Zhang Rong, Zhang Caifang, Wang Taofen   +3 more
doaj  

Positioning Control of Pneumatic Parallel Manipulator.

Journal of the Robotics Society of Japan, 1997
This paper describes one of the control methods which attain robust motion control performances of parallel manipulator. We used pneumatic cylinders as a driving actuator, focusing on air compressibility valid for the minute force control and impact absorption in environmental contact.
Masahiro Takaiwa, Toshiro Noritsugu
openaire   +2 more sources