Results 111 to 120 of about 33,423 (302)
A novel design for a hybrid space manipulator [PDF]
Described are the structural design, kinematics, and characteristics of a robot manipulator for space applications and use as an articulate and powerful space shuttle manipulator.
Shahinpoor, MO
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Jixie chuandong, 2000 In order to enrich mechanism models of spatial parallel manipulators, two novel models of 3-DOF parallel manipulators are presented. One of them is composed of two CRR limbs and one SPS limb, another is composed of two CPR limbs and one SPS limb.
赵铁石, 黄真
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
A design oriented study for 3R Orthogonal Manipulators With Geometric Simplifications [PDF]
, 2007 This paper proposes a method to calculate the largest Regular Dextrous Workspace (RDW) of some types of three-revolute orthogonal manipulators that have at least one of their DH parameters equal to zero.
Chablat, Damien +2 more
core +2 more sources
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Design and Analysis of a Spatial 3-DOF Parallel Manipulator with 2T1R-Type
International Journal of Advanced Robotic Systems, 2013 A novel asymmetrical spatial parallel manipulator with three degrees of freedom is proposed. The moving platform of the manipulator has two-translational and one-rotational (2T1R) DOFs with respect to the fixed base. Two other manipulators with platforms
Yanbin Zhang, Kwun-Lon Ting
doaj +1 more source
Kinematics and Workspace Analysis of a Three-Axis Parallel Manipulator: the Orthoglide [PDF]
, 2006 The paper addresses kinematic and geometrical aspects of the Orthoglide, a three-DOF parallel mechanism. This machine consists of three fixed linear joints, which are mounted orthogonally, three identical legs and a mobile platform, which moves in the ...
Chablat, Damien +2 more
core +2 more sources
Symbolic Elimination for Parallel Manipulators
, 1996 The forward kinematics problem of parallel robot consists in computing the position of a solid moving in the three-dimensional space with six points on it constrained to lie respectively on six given spheres. This problem can also be represented by a system of algebraic equations, and it is known to admit at most 40 complex solutions.
Tancredi, Luc +2 more
openaire +2 more sources