Results 101 to 110 of about 3,604,803 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
International Journal of Management Studies, 2004 Ordinary differential equations are commonly used for mathematical modeling in many diverse fields such as engineering, industrial mathematics, operation research, artificial intelligence, management, sociology and behavioural sciences. Numerous problems
Zurni Omar
doaj
A novel approach for large-scale hybrid mesh generation on distributed systems
Engineering Applications of Computational Fluid MechanicsThis study presents an approach for the generation of a large-scale viscous mesh using a parallel advancing layer method based on distributed systems with multi-cores.
Bohan Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Massively Parallel Computation Using Graphics Processors with Application to Optimal Experimentation in Dynamic Control [PDF]
The rapid increase in the performance of graphics hardware, coupled with recent improvements in its programmability has lead to its adoption in many non-graphics applications, including wide variety of scientific computing fields.
Morozov, Sergei, Mathur, Sudhanshu
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
High-Performance Numerical Software for Control [PDF]
, 2004 The article "High-Performance Numerical Software for Control" concerns the development of quality software for control applications that perform efficiently and reliably on today'S modern computing machines.
Delebecque, Francoise +4 more
core
Scalable data assimilation with message passing
Environmental Data ScienceData assimilation is a core component of numerical weather prediction systems. The large quantity of data processed during assimilation requires the computation to be distributed across increasingly many compute nodes; yet, existing approaches suffer ...
Oscar Key +3 more
doaj +1 more source