Results 111 to 120 of about 3,604,803 (308)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Parallel Implementation of the Katsevich's FBP Algorithm
International Journal of Biomedical Imaging, 2006 For spiral cone-beam CT, parallel computing is an effective approach to resolving the problem of heavy computation burden. It is well known that the major computation time is spent in the backprojection step for either filtered-backprojection (FBP) or ...
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Enhancing the performance of a BSP model-based parallel volume renderer with a profile visualiser [PDF]
, 2000 Volume rendering is computation intensive and can benefit from the combined processing power of a workstation cluster. Carefully balancing the workload among all workstations in the cluster is critical in achieving high efficiency in parallel volume ...
Fung, C.C., Xie, H.
core
Numerical Prediction of Flow and Heat Transfer in a Two-pass Square Channel with 90° Ribs
International Journal of Rotating Machinery, 2001 Numerical predictions of three-dimensional flow and heat transfer are presented for a two-pass square channel with ° parallel ribs. Square sectioned ribs were employed along the one side surface. The rib height-to-hydraulic diameter ratio (e/Dh) is 0.125
Yong-Jun Jang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
This is the first ever doctoral thesis in the field of DNA computation. The field has its roots in the late 1950s, when the Nobel laureate Richard Feynman first introduced the concept of computing at a molecular level. Feynman's visionary idea was only
Amos, Martyn
core
Influence of Inter-row Gap Value on Turbine Losses
International Journal of Rotating Machinery, 2001 This paper presents the results of a numerical investigation of the gap influence on the turbine efficiency. The rotor-stator interaction in a (1/2)-stage turbine is simulated by solving the quasi-three-dimensional unsteady Euler/Navier-Stokes equations ...
Paul G. A. Cizmas +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Parallel discrete event simulation on the SpiNNaker engine
, 2013 The SpiNNaker engine is a multiprocessor system, designed with a scalable interconnection system to perform real-time neural network simulation. The scalable property of the SpiNNaker system has the potential of providing high computation power making it
Chuan Bai, Bai, Chuan
core +1 more source