Results 71 to 80 of about 452,320 (290)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Altered Differentiation of Cns Neural Progenitor Cells after Transplantation into the Injured Adult Rat Spinal Cord

Cell Transplantation, 1997
Denervation of CNS neurons and peripheral organs is a consequence of traumatic SCI. Intraspinal transplantation of embryonic CNS neurons is a potential strategy for reinnervating these targets.
Stephen M. Onifer, Allison B. Cannon, Scott R. Whittemore   +2 more
doaj   +1 more source

Declaraciones de Deseo y Declaraciones de Realidad : State-Indigenous Relations and Intercultural-Bilingual Education in Peru and Guatemala [PDF]

, 2011
Ethnic diversity has historically created conflict in many nation-states throughout the globe. From the era of nation-state formation to the present, states have had various strategies for dealing with this diversity. These strategies can be divided into
Christie, Emily
core   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Activation of Brainstem Neurons During Mesencephalic Locomotor Region-Evoked Locomotion in the Cat

Frontiers in Systems Neuroscience, 2019
The distribution of locomotor-activated neurons in the brainstem of the cat was studied by c-Fos immunohistochemistry in combination with antibody-based cellular phenotyping following electrical stimulation of the mesencephalic locomotor region (MLR ...
Ioan Opris, Xiaohong Dai, Dawn M. G. Johnson, Francisco J. Sanchez, Luz M. Villamil, Songtao Xie, Cecelia R. Lee-Hauser, Stephano Chang, Larry M. Jordan, Brian R. Noga   +9 more
doaj   +1 more source

Acute flaccid paralysis with anterior myelitis - California, June 2012-June 2014. [PDF]

, 2014
In August 2012, the California Department of Public Health (CDPH) was contacted by a San Francisco Bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (AFP) associated with anterior ...
Ayscue, Patrick, Centers for Disease Control and Prevention (CDC), Clayton, Anna, Feikin, Daniel, Glaser, Carol, Harriman, Kathleen, Nix, William Allan, Padilla, Tasha, Pan, Chao, Reichel, John, Sejvar, James, Sheriff, Heather, Van Haren, Keith, Waldron, Paul, Watt, James, Waubant, Emmanuelle, Yagi, Shigeo, Yen, Cynthia   +17 more
core   +1 more source

Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. [PDF]

, 2016
The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light.
Chisholm, Andrew D, Xu, Suhong
core   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Comparative Profiling of Mouse and Human Microglial Small Extracellular Vesicles Reveals Conserved Core Functions with Distinct miRNA Signatures

Cells
Microglia-derived small extracellular vesicles (MGEVs) are key mediators of neuroimmune communication, yet their cross-species comparability and translational relevance remain poorly defined.
Amir-Hossein Bayat, Damien D. Pearse, Praveen Kumar Singh, Mousumi Ghosh   +3 more
doaj   +1 more source

Sustained Analgesic Peptide Secretion and Cell Labeling Using a Novel Genetic Modification

Cell Transplantation, 2008
Cell-based therapy for neuropathic pain could provide analgesics to local pain modulatory regions in a sustained, renewable fashion. In order to provide enhanced analgesic efficacy, transplantable cells may be engineered to produce complementary or ...
Shyam Gajavelli Ph.D., Daniel A. Castellanos, Orion Furmanski, Paul C. Schiller, Jacqueline Sagen   +4 more
doaj   +1 more source