Results 71 to 80 of about 553,826 (340)
Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder
Advanced Science, EarlyView.The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang +13 more
wiley +1 more source
Cricket Paralysis Virus Threatens Cricket Farm Business [PDF]
, 2018 Crickets are a vital source of protein for many human and animals such as frogs, geckos, lizards and are starting to make a debut as an ingredient in dog food. When crickets are consumed it is vital the crickets are free of disease (Dunn).
Marshall, Jeremy +2 more
core
Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis
Advanced Science, EarlyView.Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu +17 more
wiley +1 more source
A rare cause of acute flaccid paralysis: Human coronaviruses
Journal of Pediatric Neurosciences, 2015 Acute flaccid paralysis (AFP) is a life-threatening clinical entity characterized by weakness in the whole body muscles often accompanied by respiratory and bulbar paralysis.
Cokyaman Turgay +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.pMM‐PCL, made up of pretreated macrophage menbrane and polycaprolactone, boasts the adsorption of harmful myelin debris in the microenvironment of spinal cord injury. Abstract After spinal cord injury (SCI), a mass of myelin debris derived from injured myelin sheath will be consistently generated and induce macrophages to be foam cells.
Yuchen Zhou +7 more
wiley +1 more source
Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG. [PDF]
, 2016 The genetically encoded photosensitizer miniSOG (mini Singlet Oxygen Generator) can be used to kill cells in C. elegans. miniSOG generates the reactive oxygen species (ROS) singlet oxygen after illumination with blue light.
Chisholm, Andrew D, Xu, Suhong
core +1 more source
Advanced Science, EarlyView.This study combined microscale 3D‐printing with 2D Ti3C2Tx MXene nanosheets to produce electroconductive microfibrous micro‐meshes. By embedding these MXene‐functionalized micro‐meshes within a growth‐supportive macroporous extracellular matrix (ECM)‐based biomaterial, multifunctional biomimetic MXene‐ECM scaffolds were developed.
Ian Woods +10 more
wiley +1 more source