Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Parameter Identification of Fractional-Order Discrete Chaotic Systems
Entropy, 2019 Research on fractional-order discrete chaotic systems has grown in recent years, and chaos synchronization of such systems is a new topic. To address the deficiencies of the extant chaos synchronization methods for fractional-order discrete chaotic ...
Yuexi Peng +3 more
doaj +1 more source
From Nonlinear Identification to Linear Parameter Varying Models: Benchmark Examples
, 2018 Linear parameter-varying (LPV) models form a powerful model class to analyze and control a (nonlinear) system of interest. Identifying a LPV model of a nonlinear system can be challenging due to the difficulty of selecting the scheduling variable(s) a ...
Schoukens, Maarten, Tóth, Roland
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Zonotope parameter identification for piecewise affine system
Systems Science & Control Engineering, 2020 This paper studies one identification problem for a piecewise affine system which is a special nonlinear system. As the difficulty in identifying the piecewise affine system is to determine each separated region and each unknown parameter vector ...
Hong Jianwang +1 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Motion Parameter Identification and Motion Compensation for Shipborne HFSWR by Using the Reference RF Signal Generated at the Shore [PDF]
, 2020 Di Zhu +5 more
openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
State Estimation-based Transmission line parameter identification
Ingeniería e Investigación, 2010 This article presents two state-estimation-based algorithms for identifying transmission line parameters. The identification technique used simultaneous state-parameter estimation on an artificial power system composed of several copies of the same ...
Fredy Andrés Olarte Dussán +2 more
doaj
Ship parameter identification method based on improved wild horse optimizer
Zhongguo Jianchuan YanjiuObjectiveIt is difficult to achieve comprehensive parameter identification in multiple dimensions and degrees of freedom using traditional parameter identification methods.
Zhigang QI, Hao ZHANG, Bing LI, Zhe LU
doaj +1 more source