Results 41 to 50 of about 1,724,363 (206)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Lag quasi-synchronization of coupled delayed systems with parameter mismatch

, 2011
This paper is concerned with lag synchronization of two coupled delayed systems with parameter mismatch. Due to parameter mismatch, complete lag synchronization can not be achieved.
Wangli He (9803627), Cao, Jinde., Jinde Cao, F Qian (9854591), Han, Qing-Long., Qing-Long Han (9801650), J Cao (6848969), He, Wangli., Feng Qian, Qing-Long Han, Wangli He, Qian, Feng.   +11 more
core   +1 more source

Robust finite-control-set model predictive control for voltage source inverters against LC-filter parameter mismatch and variation

, 2022
This paper proposes a robust finite-control-set model predictive control (FCS-MPC) method for a two-level voltage source inverter (VSI) against LC-filter parameter mismatch and variation.
Hong-Hee Lee, Van-Tien Le
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Mismatch-based delayed thrombolysis: a meta-analysis [PDF]

, 2010
<p><b>Background and Purpose</b>: Clinical benefit from thrombolysis is reduced as stroke onset to treatment time increases. The use of "mismatch" imaging to identify patients for delayed treatment has face validity and has been used in
Lees, K.R., Mishra, N.K., Donnan, G.A., Furlan, A.J., Hacke, W., Geoffrey A. Donnan, Nishant K. Mishra, Stephen M. Davis, Kennedy R. Lees, Anthony J. Furlan, Werner Hacke, Gregory W. Albers   +11 more
core   +1 more source

Digital Calibration for Gain, Time Skew, and Bandwidth Mismatch in Under-Sampling Time-Interleaved System

Applied Sciences, 2022
This paper presents an all-digital background calibration method for gain, time skew, and bandwidth mismatch in M-channel under-sampling time-interleaved analog-to-digital converters (TI-ADCs) systems.
Min Hu, Pengxing Yi
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Complex-Polynomial Compensation of Wideband Harmonic Measurement Errors: A Closed-Loop Fluxgate Sensor Model Study

Energies
Finite feedback dynamics cause frequency-dependent errors in harmonic current measurement. This work presents a theoretical and numerical study of complex-polynomial compensation for a closed-loop fluxgate sensor model.
Hongda Dou, Zelin Huo, Qingfeng Li, Zhenhua Li   +3 more
doaj   +1 more source