Results 91 to 100 of about 1,479,521 (268)

Whale optimization algorithm with nonlinear control parameter

MATEC Web of Conferences, 2017
Whale optimization algorithm (WOA) is a relatively novel intelligence optimization technique which has been shown to be competitive to other population-based algorithms.
Zhong Minghui, Long Wen
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Comparison of process parameter optimization using different designs in nanoemulsion-based formulation for transdermal delivery of fullerene

International Journal of Nanomedicine, 2014
Cheng Loong Ngan,1 Mahiran Basri,1,2 Fui Fang Lye,1 Hamid Reza Fard Masoumi,1 Minaketan Tripathy,3,4 Roghayeh Abedi Karjiban,1 Emilia Abdul-Malek1 1Department of Chemistry, Faculty of Science, 2Halal Products Research Institute, Universiti Putra Malaysia,
Ngan CL, Basri M, Lye FF, Fard Masoumi HR, Tripathy M, Karjiban RA, Abdul-Malek E   +6 more
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Study on the Impact of Input Parameters on Seawater Dissolved Oxygen Prediction Models

Journal of Marine Science and Engineering
The concentration of dissolved oxygen (DO) in seawater is a core ecological indicator in aquaculture, and its accurate prediction is of great value for the management of marine ranching.
Wenqing Li, Jing Lv, Yuhang Wang, Xiangfeng Kong   +3 more
doaj   +1 more source

Spaciotemporal optimization of mesh moving techniques for fluid-structure interactions

Nihon Kikai Gakkai ronbunshu, 2018
In mesh-based fluid-structure interaction (FSI) analysis, mesh moving techniques are essential for preventing mesh distortion and improving the robustness of FSI analysis.
Yuki YAMAMOTO, Giwon HONG, Naoto MITSUME, Tomonori YAMADA, Shinobu YOSHIMURA   +4 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Parameter Adaptive Manta Ray Foraging Optimization for Global Continuous Optimization Problems and Parameter Estimation of Solar Photovoltaic Models

International Journal of Computational Intelligence Systems
The manta ray foraging optimization (MRFO) algorithm suffers from a fixed parameter $$ S $$ S , limiting its adaptability in balancing search capability and convergence speed during different optimization stages.
Zhentao Tang, Kaiyu Wang, Yongxuan Yao, Mingxin Zhu, Lan Zhuang, Huiqin Chen, Jing Li, Li Yan, Shangce Gao   +8 more
doaj   +1 more source