Results 101 to 110 of about 811,356 (270)

Multi-parameter uncertainty analysis of a bifurcation point [PDF]

Nonlinear Processes in Geophysics, 2006
Parameter uncertainty analysis of climate models has become a standard approach for model validation and testing their sensitivity. Here we present a novel approach that allows one to estimate the robustness of a bifurcation point in a multi-parameter ...
B. Knopf, M. Flechsig, K. Zickfeld
doaj  

The Robustness of ‘Enemy-of-My-Enemy-is-My-Friend’ Alliances [PDF]

This paper examines the robustness of alliance formation in a three-player, two-stage game in which each of two players compete against a third player in disjoint sets of contests.
Brian Roberson, David Rietzke
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Optimizing PID controller parameters for robust automatic voltage regulator system through indirect design approach-2

Global Energy Interconnection
Automatic voltage regulators (AVR) are designed to manipulate a synchronous generator’s voltage level automatically. Proportional integral derivative (PID) controllers are typically used in AVR systems to regulate voltage.
Mohd Zaidi Mohd Tumari, Mohd Ashraf Ahmad, Mohd Riduwan Ghazali, Mohd Helmi Suid   +3 more
doaj   +1 more source

Computational analysis of viable parameter regions in models of synthetic biological systems

Journal of Biological Engineering, 2019
Background Gene regulatory networks with different topological and/or dynamical properties might exhibit similar behavior. System that is less perceptive for the perturbations of its internal and external factors should be preferred.
Žiga Pušnik, Miha Mraz, Nikolaj Zimic, Miha Moškon   +3 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Online Gradient Descent for Kernel-Based Maximum Correntropy Criterion

Entropy, 2019
In the framework of statistical learning, we study the online gradient descent algorithm generated by the correntropy-induced losses in Reproducing kernel Hilbert spaces (RKHS).
Baobin Wang, Ting Hu
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Stability Control of the DC/DC Converter in DC Microgrids Considering Negative Damping and Parameter Uncertainties

Energies
To address the issue of negative damping instability easily induced by DC/DC converters under constant power load (CPL) in DC microgrids and to enhance the control robustness of the system under uncertainties such as parameter perturbations, this paper ...
Hao Deng, Wusong Wen, Yingchao Zhang, Sheng Long, Liping Jin   +4 more
doaj   +1 more source